Gharaibeh Mohammad Y, Batayneh Sajida, Khabour Omar F, Daoud Azhar
Departments of Medical Laboratory Sciences, and.
Exp Ther Med. 2010 Jul;1(4):701-705. doi: 10.3892/etm_00000108. Epub 2010 Jul 1.
Attention deficit hyperactivity disorder (ADHD) is one of the most common neuropsychiatric disorders in children. In this study, the association between 10-repeats in the DAT1 gene and the (GT)n repeat in the DBH gene and ADHD was examined in children from Jordan. In addition, the levels of dopamine-β-hydroxylase enzyme activity in the plasma of ADHD children were evaluated. Fifty children with ADHD and 50 age- and gender-matched control subjects were recruited. The results showed significant differences between the ADHD group and controls with respect to the plasma levels of dopamine-β-hydroxylase enzyme activity (25.4±2.3 vs. 84.7±5.0 μmol/min; p<0.01). Moreover, the 10-repeat DAT1 gene and (GT)n DBH gene polymorphisms were significantly associated with ADHD development (p<0.05). In conclusion, the DBH and DAT1 genes appear to play a role in the development of ADHD in the Jordanian population.
注意缺陷多动障碍（ADHD）是儿童中最常见的神经精神疾病之一。在本研究中，对来自约旦的儿童进行了DAT1基因中的10次重复与DBH基因中的(GT)n重复及ADHD之间关联的研究。此外，还评估了ADHD儿童血浆中多巴胺-β-羟化酶的活性水平。招募了50名患有ADHD的儿童和50名年龄及性别匹配的对照受试者。结果显示，ADHD组与对照组在多巴胺-β-羟化酶活性的血浆水平方面存在显著差异（25.4±2.3对84.7±5.0 μmol/min；p<0.01）。此外，10次重复的DAT1基因和(GT)n DBH基因多态性与ADHD的发生显著相关（p<0.05）。总之，DBH和DAT1基因似乎在约旦人群ADHD的发生中起作用。
