约旦儿童中DBH和DAT1基因多态性与注意力缺陷多动障碍之间的关联。
Association between polymorphisms of the DBH and DAT1 genes and attention deficit hyperactivity disorder in children from Jordan.
作者信息
Gharaibeh Mohammad Y, Batayneh Sajida, Khabour Omar F, Daoud Azhar
机构信息
Departments of Medical Laboratory Sciences, and.
出版信息
Exp Ther Med. 2010 Jul;1(4):701-705. doi: 10.3892/etm_00000108. Epub 2010 Jul 1.
Attention deficit hyperactivity disorder (ADHD) is one of the most common neuropsychiatric disorders in children. In this study, the association between 10-repeats in the DAT1 gene and the (GT)n repeat in the DBH gene and ADHD was examined in children from Jordan. In addition, the levels of dopamine-β-hydroxylase enzyme activity in the plasma of ADHD children were evaluated. Fifty children with ADHD and 50 age- and gender-matched control subjects were recruited. The results showed significant differences between the ADHD group and controls with respect to the plasma levels of dopamine-β-hydroxylase enzyme activity (25.4±2.3 vs. 84.7±5.0 μmol/min; p<0.01). Moreover, the 10-repeat DAT1 gene and (GT)n DBH gene polymorphisms were significantly associated with ADHD development (p<0.05). In conclusion, the DBH and DAT1 genes appear to play a role in the development of ADHD in the Jordanian population.
注意缺陷多动障碍（ADHD）是儿童中最常见的神经精神疾病之一。在本研究中，对来自约旦的儿童进行了DAT1基因中的10次重复与DBH基因中的(GT)n重复及ADHD之间关联的研究。此外，还评估了ADHD儿童血浆中多巴胺-β-羟化酶的活性水平。招募了50名患有ADHD的儿童和50名年龄及性别匹配的对照受试者。结果显示，ADHD组与对照组在多巴胺-β-羟化酶活性的血浆水平方面存在显著差异（25.4±2.3对84.7±5.0 μmol/min；p<0.01）。此外，10次重复的DAT1基因和(GT)n DBH基因多态性与ADHD的发生显著相关（p<0.05）。总之，DBH和DAT1基因似乎在约旦人群ADHD的发生中起作用。
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