Thursina Cempaka, Nurputra Dian Kesumapramudya, Harahap Indra Sari Kusuma, Harahap Nur Imma Fatimah, Sa'adah Nihayatus, Wibowo Samekto, Sutarni Sri, Sadewa Ahmad Hamim, Hanjaya Hermawan, Nishio Hisahide
Doctoral Programme of Medical and Health Science, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Department of Neurology, Faculty of Medicine Universitas Gadjah Mada, Yogyakarta, Indonesia.
Neurol Int. 2020 Jul 10;12(1):8292. doi: 10.4081/ni.2020.8292.
Attention deficit hyperactivity disorder (ADHD) is one of the most common neurobehavioural in the children. Genetic factor is known one of the factors which contributed in ADHD development. VNTR polymorphism in 3'UTR exon 15 of DAT1 gene and exon 3 of DRD4 gene are reported to be associated in ADHD. In this study we examine the association of ADHD with VNTR polymorphism of DAT1 and DRD4 gene in Indonesian children. Sixty-five ADHD children and 70 normal children (6-13 years of age), were included in the study, we matched by age and gender. ADHD was diagnosed by DSM-IV. We performed a casecontrol study to found the association between ADHD and VNTR polymorphism of DAT1 and DRD4 genes. The 10-repeat allele of DAT1 and 2-repeat allele of DRD4 were higher in Indonesian children. Although the frequency of these allele was higher, but it was similar both in ADHD and control groups. Neither DAT1 nor DRD4 gene showed showed significant difference in genotype distribution and frequency allele between both groups (p > 0.05) No association between ADHD and VNTR polymorphism of DAT1 and DRD4 genes found in Indonesian children. This data suggest that DAT1 and DRD4 do not contribute to etiology of ADHD in Indonesian children. Further studies are needed to clarify association between VNTR polymorphism of DAT1 and DRD4 genetic with ADHD of Indonesian children in larger sample size and family based study.
注意缺陷多动障碍（ADHD）是儿童中最常见的神经行为疾病之一。遗传因素是已知的导致ADHD发病的因素之一。据报道，DAT1基因3'UTR外显子15和DRD4基因外显子3中的VNTR多态性与ADHD有关。在本研究中，我们检测了印度尼西亚儿童中ADHD与DAT1和DRD4基因VNTR多态性的相关性。本研究纳入了65名ADHD儿童和70名正常儿童（6 - 13岁），按年龄和性别进行匹配。ADHD由DSM - IV诊断。我们进行了一项病例对照研究，以发现ADHD与DAT1和DRD4基因VNTR多态性之间的关联。DAT1基因的10重复等位基因和DRD4基因的2重复等位基因在印度尼西亚儿童中比例更高。尽管这些等位基因的频率较高，但在ADHD组和对照组中相似。两组之间DAT1和DRD4基因在基因型分布和等位基因频率上均无显著差异（p>0.05）。在印度尼西亚儿童中未发现ADHD与DAT1和DRD4基因VNTR多态性之间的关联。该数据表明，DAT1和DRD4对印度尼西亚儿童ADHD的病因没有影响。需要进一步的研究，以更大的样本量和基于家系的研究来阐明DAT1和DRD4基因VNTR多态性与印度尼西亚儿童ADHD之间的关联。
