Naganawa Yasuhiro, Ishiguro Hideyuki, Kuwabara Yoshiyuki, Kimura Masahiro, Mitsui Akira, Katada Takeyasu, Tanaka Tatsuya, Shiozaki Midori, Fujii Yoshitaka, Takeyama Hiromitsu
Gastroenterological Surgery, and.
Exp Ther Med. 2010 Sep;1(5):841-846. doi: 10.3892/etm.2010.115. Epub 2010 Jul 12.
FBXW7 is a tumor suppressor gene that induces the degradation of positive cell-cycle regulators such as c-Myc, cyclin E, c-Jun and Notch. The loss of FBXW7 promotes cell-cycle progression and cell proliferation. In the present study, we investigated the relationship between FBXW7 expression and the clinicopathological characteristics of patients with esophageal squamous cell carcinoma (ESCC). The expression of FBXW7 was quantified by real-time reverse transcription polymerase chain reaction in 43 primary ESCCs and their paired normal esophageal mucosa in patients who had not received preoperative therapy. FBXW7 expression levels were significantly correlated with the progression of the cancer and with local invasiveness. In muscle-invasive tumor cases (T2-4), lymphatic invasive tumor cases and stage II-IV cases, FBXW7 expression levels were significantly decreased (P=0.0315, P=0.0336 and P=0.0289, respectively). Decreased expression of FBXW7 was correlated with poor prognosis (P=0.0255). In conclusion, this study examined the relationship between FBXW7 expression and tumor progression in ESCC. We suggest that FBXW7 is a molecular prognostic marker and can be used to elucidate the mechanism of carcinogenesis.
FBXW7是一种肿瘤抑制基因，可诱导c-Myc、细胞周期蛋白E、c-Jun和Notch等细胞周期正向调节因子的降解。FBXW7的缺失会促进细胞周期进程和细胞增殖。在本研究中，我们调查了FBXW7表达与食管鳞状细胞癌（ESCC）患者临床病理特征之间的关系。通过实时逆转录聚合酶链反应对43例未经术前治疗的原发性ESCC及其配对的正常食管黏膜中FBXW7的表达进行定量。FBXW7表达水平与癌症进展和局部侵袭性显著相关。在肌层浸润性肿瘤病例（T2-4）、淋巴浸润性肿瘤病例和II-IV期病例中，FBXW7表达水平显著降低（分别为P=0.0315、P=0.0336和P=0.0289）。FBXW7表达降低与预后不良相关（P=0.0255）。总之，本研究探讨了ESCC中FBXW7表达与肿瘤进展之间的关系。我们认为FBXW7是一种分子预后标志物，可用于阐明致癌机制。
