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本文引用的文献

1
Decreased expression of FBXW7 is correlated with poor prognosis in patients with esophageal squamous cell carcinoma.FBXW7表达降低与食管鳞状细胞癌患者的不良预后相关。
Exp Ther Med. 2010 Sep;1(5):841-846. doi: 10.3892/etm.2010.115. Epub 2010 Jul 12.
2
Clinical significance of the gene expression profile in residual tumor cells after neoadjuvant chemo-radiotherapy for esophageal cancer.新辅助放化疗后食管癌残留肿瘤细胞中基因表达谱的临床意义
Oncol Rep. 2009 Jun;21(6):1489-94. doi: 10.3892/or_00000379.
3
Using Q-RT-PCR to measure cyclin D1, TS, TP, DPD, and Her-2/neu as predictors for response, survival, and recurrence in patients with esophageal squamous cell carcinoma following radiochemotherapy.使用定量逆转录聚合酶链反应（Q-RT-PCR）检测细胞周期蛋白D1、胸苷合成酶（TS）、拓扑异构酶（TP）、二氢嘧啶脱氢酶（DPD）和人表皮生长因子受体2（Her-2/neu），以预测食管鳞状细胞癌患者放化疗后的反应、生存和复发情况。
Int J Colorectal Dis. 2009 Jan;24(1):69-77. doi: 10.1007/s00384-008-0562-5. Epub 2008 Aug 13.
4
Relationship between expression of 5-fluorouracil metabolic enzymes and 5-fluorouracil sensitivity in esophageal carcinoma cell lines.5-氟尿嘧啶代谢酶表达与食管癌细胞系中5-氟尿嘧啶敏感性之间的关系
Dis Esophagus. 2008;21(1):15-20. doi: 10.1111/j.1442-2050.2007.00700.x.
5
Expression of ACP6 is an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma.酸性磷酸酶6（ACP6）的表达是食管鳞状细胞癌患者生存预后不良的独立危险因素。
Oncol Rep. 2006 Jun;15(6):1551-5.
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The role of thymidylate synthase and dihydropyrimidine dehydrogenase in resistance to 5-fluorouracil in human lung cancer cells.胸苷酸合成酶和二氢嘧啶脱氢酶在人肺癌细胞对5-氟尿嘧啶耐药性中的作用。
Lung Cancer. 2005 Sep;49(3):345-51. doi: 10.1016/j.lungcan.2005.05.003.
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Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in relation to differentiation of gastric cancer.胸苷酸合成酶和二氢嘧啶脱氢酶基因表达与胃癌分化的关系
Int J Cancer. 2004 Dec 20;112(6):967-73. doi: 10.1002/ijc.20511.
8
Intratumoral dihydropyrimidine dehydrogenase messenger RNA level reflects tumor progression in human colorectal cancer.肿瘤内二氢嘧啶脱氢酶信使核糖核酸水平反映人类结直肠癌的肿瘤进展。
Ann Surg Oncol. 2002 Jul;9(6):599-603. doi: 10.1007/BF02573898.
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Roles of thymidylate synthase and dihydropyrimidine dehydrogenase in tumor progression and sensitivity to 5-fluorouracil in human gastric cancer.胸苷酸合成酶和二氢嘧啶脱氢酶在人胃癌肿瘤进展及对5-氟尿嘧啶敏感性中的作用
Anticancer Res. 2002 Mar-Apr;22(2A):761-8.
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Expression of thymidylate synthase and thymidine phosphorylase in recurrence and survival rates of advanced gastric cancer.胸苷酸合成酶和胸苷磷酸化酶的表达与进展期胃癌复发率及生存率的关系
Gastric Cancer. 1999 Nov;2(3):165-172. doi: 10.1007/s101200050041.

食管癌中胸苷酸合成酶和二氢嘧啶脱氢酶的mRNA水平

Thymidylate synthetase and dihydropyrimidine dehydrogenase mRNA levels in esophageal cancer.

作者信息

Kimura Masahiro, Kuwabara Yoshiyuki, Mitsui Akira, Ishiguro Hideyuki, Sugito Nobuyoshi, Tanaka Tatsuya, Shiozaki Midori, Naganawa Yasuhiro, Takeyama Hiromitsu

机构信息

Department of Gastroenterological Surgery, Nagoya City University, Graduate School of Medical Science, Nagoya 467-8601, Japan.

出版信息

Oncol Lett. 2011 Mar;2(2):297-301. doi: 10.3892/ol.2010.227. Epub 2010 Dec 16.

DOI:10.3892/ol.2010.227
PMID:22866080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3410576/
Abstract

This study investigated the mRNA levels of thymidylate synthetase (TYMS) and dihydropyrimidine dehydrogenase (DPYD) in esophageal squamous cell carcinoma (ESCC). TYMS and DPYD gene expression was quantified using real-time RT-PCR in 56 patients with ESCC, co-amplified with glyceraldehyde-3-phosphate dehydrogenase as an internal standard. The results were analyzed with reference to the clinicopathological characteristics and the prognosis of the ESCC patients. The TYMS and DPYD expression levels in patients positive with lymphatic invasion were significantly higher compared to those in patients who exhibited negative lymphatic invasion (TYMS P=0.0127, DPYD P=0.0127). Patients were classified into the groups high TYMS/DPYD, high TYMS but low DPYD, low TYMS but high DPYD and low TYMS/DPYD. The highest survival rate was found in the group with low TYMS/DPYD and the lowest survival rate in the group with high TYMS/DPYD (P=0.017). It was concluded that, on the basis of the multivariate analysis, TYMS mRNA expression is a candidate that serves as an independent prognostic factor for ESCC patients.

摘要

本研究调查了食管鳞状细胞癌（ESCC）中胸苷酸合成酶（TYMS）和二氢嘧啶脱氢酶（DPYD）的mRNA水平。采用实时逆转录聚合酶链反应（RT-PCR）对56例ESCC患者的TYMS和DPYD基因表达进行定量分析，并以甘油醛-3-磷酸脱氢酶作为内参进行共扩增。结合ESCC患者的临床病理特征和预后对结果进行分析。与无淋巴转移的患者相比，有淋巴转移的患者中TYMS和DPYD的表达水平显著更高（TYMS P = 0.0127，DPYD P = 0.0127）。患者被分为高TYMS/DPYD组、高TYMS但低DPYD组、低TYMS但高DPYD组和低TYMS/DPYD组。低TYMS/DPYD组的生存率最高，高TYMS/DPYD组的生存率最低（P = 0.017）。多因素分析结果表明，TYMS mRNA表达可作为ESCC患者独立的预后因素。