Department of Emergency Medicine, Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Jacobi Medical Center, Bronx, NY, USA.
Acad Emerg Med. 2012 Oct;19(10):1181-7. doi: 10.1111/j.1553-2712.2012.01453.x. Epub 2012 Sep 20.
Postexposure prophylaxis (PEP) has substantially reduced the risk of acquiring human immunodeficiency virus (HIV) after an occupational exposure; nevertheless, exposure to HIV remains a concern for emergency department providers. According to published guidelines, PEP should be taken only when source patients are HIV-positive or have risk factors for HIV. Initiating PEP when source patients are uninfected puts exposed persons at risk from taking toxic drugs with no compensating benefit. Forgoing PEP if the source is infected results in increased risk of acquiring HIV. What should be done if source patients refuse HIV testing? Is it justifiable to test the blood of these patients over their autonomous objection? The authors review current law and policy and perform an ethical analysis to determine if laws permitting unconsented testing in cases of occupational exposure can be ethically justified.
职业暴露后预防(PEP)大大降低了职业暴露后感染人类免疫缺陷病毒(HIV)的风险;然而,HIV 的暴露仍然是急诊医生关注的问题。根据已发表的指南,仅在源患者 HIV 阳性或有 HIV 风险因素时才应服用 PEP。在源患者未感染的情况下开始 PEP 会使暴露者面临服用有毒药物而没有补偿益处的风险。如果源患者感染而不进行 PEP,则会增加感染 HIV 的风险。如果源患者拒绝 HIV 检测该怎么办?是否可以在违背这些患者自主意愿的情况下对其血液进行检测?作者审查了现行法律和政策,并进行了伦理分析,以确定在职业暴露的情况下允许未经同意进行检测的法律是否在伦理上是合理的。