结直肠黏液腺癌的TNM分期及预后特征：一项荟萃分析
TNM stages and prognostic features of colorectal mucinous adenocarcinomas: a meta analysis.
作者信息
Chen Jing-Xiang, Tang Xu-Dong, Xiang De-Bing, Dong Xiao-Ling, Peng Fang-Yi, Sun Gui-Yin
机构信息
Department of Emergency, Jiangjin Central Hospital, Chongqing, China.
出版信息
Asian Pac J Cancer Prev. 2012;13(7):3427-30. doi: 10.7314/apjcp.2012.13.7.3427.
AIM
The significance of the mucinous adenocarcinoma in TNM staging and prognosis for colorectal tumor patients is still controversial. The aim was to provide a meta-analysis for TNM staging and prognostic features of colorectal tumors.
METHODS
30 individual case-control studies were finally included into this meta-analysis, involving a total of 444,489 cancer cases and 45,050 mucinous adenocarcinomas, of relations with TNM staging and prognostic features.
RESULTS
Compared to non-mucinous adenocarcinoma patients, the TNM IV stage accounted for a larger percentage of mucinous adenocarcinomas (OR=1.48, 95%CI 1.28-1.71, POR<0.001) and the prognosis was significantly poor (HR=1.06, 95%CI 1.04-1.08, P<0.001). After heterogeneity testing, the results was similar to the holistic approach outcome (HR=1.48, 95%CI 1.35-1.62, P<0.001).
CONCLUSION
Compared to patients with non-mucinous adenocarcinomas, mucinous adenocarcinoma patients with later TNM staging make up a big percentage, and mucinous adenocarcinoma is an independent risk factor for poor prognosis.
目的
黏液腺癌在结直肠肿瘤患者TNM分期及预后中的意义仍存在争议。本研究旨在对结直肠肿瘤的TNM分期及预后特征进行荟萃分析。
方法
本荟萃分析最终纳入30项个体病例对照研究，共涉及444,489例癌症病例和45,050例黏液腺癌病例，分析其与TNM分期及预后特征的关系。
结果
与非黏液腺癌患者相比，黏液腺癌患者中TNM IV期所占比例更大（OR = 1.48，95%CI 1.28 - 1.71，P < 0.001），且预后明显较差（HR = 1.06，95%CI 1.04 - 1.08，P < 0.001）。经过异质性检验，结果与整体分析结果相似（HR = 1.48，95%CI 1.35 - 1.62，P < 0.001）。
结论
与非黏液腺癌患者相比，TNM分期较晚的黏液腺癌患者占比大，黏液腺癌是预后不良的独立危险因素。
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