Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Biochem Biophys Res Commun. 2012 Oct 26;427(3):441-3. doi: 10.1016/j.bbrc.2012.09.058. Epub 2012 Sep 18.
Cardiovascular complications account for significant morbidity and mortality in the diabetic population. Diabetic cardiomyopathy (DCM), a prominent cardiovascular complication, has been recognized as a microvascular disease that may lead to heart failure. During the past few decades, research progress has been made in investigating the pathophysiology of the disease; however, the exact molecular mechanism has not been elucidated, making therapeutic a difficult task. In this review article, we have discussed a number of diabetes-induced metabolites such as glucose, advanced glycation end products, protein kinase C, free fatty acid and oxidative stress and other related factors that are implicated in the pathophysiology of the DCM. An understanding of the biochemical and molecular changes especially early in the DCM may lead to new and effective therapies toward prevention and amelioration of DCM, which is important for the millions of individuals who already have or are likely to develop the disease before a cure becomes available.
心血管并发症是糖尿病患者发病率和死亡率的主要原因。糖尿病心肌病（DCM）是一种主要的心血管并发症，已被认为是一种微血管疾病，可能导致心力衰竭。在过去的几十年中，人们在研究疾病的病理生理学方面取得了进展；然而，确切的分子机制尚未阐明，这使得治疗变得困难。在这篇综述文章中，我们讨论了一些糖尿病诱导的代谢物，如葡萄糖、糖基化终产物、蛋白激酶 C、游离脂肪酸和氧化应激等相关因素，这些因素与 DCM 的病理生理学有关。了解 DCM 早期的生化和分子变化可能会导致新的、有效的治疗方法，预防和改善 DCM，这对已经患有或可能在治愈前患上这种疾病的数百万人来说非常重要。
