Peripheral Vessels Unit, 1st Cardiology Department, Athens Medical School, Hippokration Hospital, Athens, Greece.
Hellenic J Cardiol. 2012 Sep-Oct;53(5):352-6.
Aortic stiffness is a valuable biomarker for stratifying cardiovascular risk. NADPH oxidase regulates oxidative status in vessels; its single nucleotide polymorphisms (SNPs) modify the redox state of carriers and may lead to noxious structural alterations and affect the vasomotor properties of arteries. We hypothesized that genetic variability of NADPH oxidase would be accompanied by differences in aortic stiffness; to this end, we explored the interplay of pulse wave velocity (PWV), a measure of aortic stiffness, with common SNPs of the CYBA gene that encodes the p22phox subunit of NADPH oxidase.
289 young, healthy adults were studied. The -930A/G, A640G and C242T CYBA SNPs were genotyped and PWV was measured. Differences in PWV across genotypes were examined in unadjusted models and after adjustment for confounders.
Genetic variability of the examined SNPs did not result in changes of aortic stiffness. In unadjusted models, PWV did not differ across genotypes for the -930A/G (p=0.20), A640G (p=0.65) or C242T SNP (p=0.50). In stepwise multiple linear regression analysis only sex, age and systolic blood pressure emerged as independent predictors of PWV.
Common genetic variants of NADPH oxidase do not influence aortic stiffness in young, healthy adults.
主动脉僵硬是分层心血管风险的有价值的生物标志物。NADPH 氧化酶调节血管中的氧化状态；其单核苷酸多态性（SNPs）改变了载体的氧化还原状态，可能导致有害的结构改变，并影响动脉的血管运动特性。我们假设 NADPH 氧化酶的遗传变异会伴随着主动脉僵硬的差异；为此，我们探讨了脉搏波速度（PWV），一种主动脉僵硬的衡量标准，与编码 NADPH 氧化酶 p22phox 亚基的 CYBA 基因的常见 SNPs 之间的相互作用。
研究了 289 名年轻健康的成年人。对 CYBA 基因的-930A/G、A640G 和 C242T SNP 进行了基因分型，并测量了 PWV。在未调整模型和调整混杂因素后，检查了基因型之间 PWV 的差异。
所检查的 SNPs 的遗传变异并未导致主动脉僵硬的变化。在未调整模型中，-930A/G（p=0.20）、A640G（p=0.65）或 C242T SNP（p=0.50）的基因型之间 PWV 没有差异。在逐步多元线性回归分析中，只有性别、年龄和收缩压是 PWV 的独立预测因素。
NADPH 氧化酶的常见遗传变异不会影响年轻健康成年人的主动脉僵硬。
