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[女性生殖道的固有免疫和适应性免疫]

[Innate and adaptative immunity of the female genital tract].

作者信息

Lepargneur J-P, Abbal M

机构信息

Faculté de médecine de Toulouse Rangueil, université Paul-Sabatier, Toulouse, France.

出版信息

J Gynecol Obstet Biol Reprod (Paris). 2012 Nov;41(7):612-22. doi: 10.1016/j.jgyn.2012.07.006. Epub 2012 Sep 17.

Abstract

Most of molecules and cells involved in both types, innate and adaptive immunity are present within the feminine genital tract. This article attempts to list some of the various actors involved in these immunities, essentially at the vaginal level and to illustrate their implications in the most frequent pathologies. Among these molecules: defensins, collectins lysozyme, lactoferrin, calprotectin, SLP1, HSP and many others as well as Toll receptors and immunoglobulins (IgG and IgA) play a major role. Epithelial cells, antigen presenting cells, lymphocytes T, B, NK also contribute efficiently to the defenses in a coordinated way partially under the influence of sex hormones. The therapeutic perspectives, of which vaccines are briefly mentioned.

摘要

参与先天性免疫和适应性免疫这两种免疫类型的大多数分子和细胞都存在于女性生殖道内。本文试图列出参与这些免疫的一些不同参与者,主要是在阴道层面,并说明它们在最常见病理中的影响。在这些分子中:防御素、凝集素、溶菌酶、乳铁蛋白、钙卫蛋白、SLP1、热休克蛋白等以及Toll样受体和免疫球蛋白(IgG和IgA)发挥着重要作用。上皮细胞、抗原呈递细胞、T淋巴细胞、B淋巴细胞、自然杀伤细胞也在性激素的部分影响下以协调的方式有效地促进防御。还简要提及了治疗前景,其中包括疫苗。

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