Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan; Mackay Medical College, New Taipei City, Taiwan.
J Surg Oncol. 2013 Apr;107(5):493-7. doi: 10.1002/jso.23270. Epub 2012 Sep 20.
Inflammation has been implicated in the initiation and progression of thyroid cancer. Neutrophil-to-lymphocyte ratio (NLR) is a simple index of systemic inflammatory response, and has been shown to be a prognostic indicator in some types of cancer. The aim of this study was to examine the relationship between NLR and clinicopathological features in patients with differentiated thyroid cancer.
Total white blood cell and differential counts of 159 patients with differentiated thyroid cancer were compared to those of 318 age- and sex-matched controls undergoing thyroidectomy for benign thyroid nodules. Clinicopathological variables, stratified by NLR tertiles, were analyzed.
There was no difference in NLR between patients having benign and malignant thyroid nodules (P = 0.293). Cancer patients in the higher NLR tertile had significantly larger tumor size (P = 0.004). Higher NLR was observed in patients with high American Thyroid Association (ATA) risk of recurrence.
High preoperative NLR was associated with increased tumor size and high ATA risk of recurrence in patients with differentiated thyroid cancer.
炎症与甲状腺癌的发生和进展有关。中性粒细胞与淋巴细胞比值（NLR）是全身炎症反应的一个简单指标，已被证明是某些类型癌症的预后指标。本研究旨在探讨 NLR 与分化型甲状腺癌患者临床病理特征之间的关系。
比较了 159 例分化型甲状腺癌患者和 318 例因良性甲状腺结节行甲状腺切除术的年龄和性别匹配对照者的总白细胞和白细胞分类计数。分析了 NLR 三分位组的临床病理变量。
良性和恶性甲状腺结节患者的 NLR 无差异（P=0.293）。 NLR 较高三分位的癌症患者肿瘤大小明显更大（P=0.004）。 NLR 较高的患者美国甲状腺协会（ATA）复发风险较高。
术前高 NLR 与分化型甲状腺癌患者肿瘤增大和 ATA 高复发风险相关。
