Gonda Kenji, Shibata Masahiko, Ohtake Tohru, Yasuda Mitsuhiko, Abe Noriko, Watanabe Kumiko, Ando Jin, Okano Maiko, Onozawa Hisashi, Tachibana Kazunoshin, Ohto Hitoshi, Takenoshita Seiichi
Dept. of Organ Regulatory Surgery, Fukushima Medical University.
Gan To Kagaku Ryoho. 2012 Sep;39(9):1363-8.
Myeloid-derived suppressor cells (MDSC) are one of the major cell populations responsible for regulating immune responses. These cells have been reported to accumulate in the blood, lymph nodes, and tumor sites in most patients during tumor progression and in chronic infection. They are also reported to potently suppress T-cell functions. We studied MDSC in the peripheral blood mononuclear cells(PBMC)by flow cytometry using blood samples from 29 patients with breast cancer, and from 11 healthy donors. The cell level was significantly high for patients compared to the 11 healthy donors (5. 68±6. 09% vs. 0. 91±0. 54%). MDSC was significantly higher in all of the breast cancer patients (5. 68±6. 09%), preoperative patients (5. 79±4. 92%) and recurrent disease patients (5. 59±7. 28%), compared to healthy donors, but not for postoperative patients (1. 50±0. 95%). Thus, MDSC was elevated in patients with breast cancer, but decreased to the range of healthy individuals after the removal of the tumor mass. However, MDSC increased again with recurrence. We also report that in 2 cases, MDSC in the peripheral blood and pleural effusion of patients with metastatic breast cancer decreased after chemotherapy with gemcitabine.
髓源性抑制细胞（MDSC）是负责调节免疫反应的主要细胞群体之一。据报道，在肿瘤进展和慢性感染期间，大多数患者的这些细胞会在血液、淋巴结和肿瘤部位积聚。据报道，它们还能有效抑制T细胞功能。我们使用29例乳腺癌患者和11名健康供体的血样，通过流式细胞术研究外周血单个核细胞（PBMC）中的MDSC。与11名健康供体相比，患者的细胞水平显著升高（5.68±6.09%对0.91±0.54%）。与健康供体相比，所有乳腺癌患者（5.68±6.09%）、术前患者（5.79±4.92%）和复发性疾病患者（5.59±7.28%）的MDSC均显著升高，但术后患者（1.50±0.95%）则不然。因此，乳腺癌患者的MDSC升高，但在切除肿瘤块后降至健康个体的范围。然而，MDSC随着复发再次升高。我们还报告了2例转移性乳腺癌患者在吉西他滨化疗后外周血和胸腔积液中的MDSC减少。
