Yamashita Kaname, Ishikawa Daisuke, Nanjo Shigeki, Takeuchi Shinji, Yamada Tadaaki, Mouri Hisatsugu, Ohtsubo Koushiro, Yasumoto Kazuo, Kumagai Masashi, Ueda Yoshimichi, Yano Seiji
Cancer Center, Kanazawa University Hospital.
Gan To Kagaku Ryoho. 2012 Sep;39(9):1427-30.
A 74-year-old woman diagnosed with poorly-differentiated neuroendocrine carcinoma originating from the ascending colon was referred to our hospital. She had felt anorexia, abdominal pains and her (ECOG) performance status was 3. Her CT scan showed that some abdominal lymph nodes were swelling and that there were many metastatic lesions occupying most of the liver. We started chemotherapy with cisplatin and irinotecan according to a regimen for small cell lung cancer. Considering her poor PS, both of the drugs were administered at 30mg/m² twice 4 weeks in the first course of chemotherapy. Her anorexia and abdominal pains immediately disappeared, and CT scan showed that all of the metastases were decreased in size. After 4 courses, however, some of the metastatic lesions were increased in size. She died 8 months after diagnosis. The tumor marker doubling time was 17 days.
一名74岁女性，被诊断为起源于升结肠的低分化神经内分泌癌，转诊至我院。她有厌食、腹痛症状，东部肿瘤协作组（ECOG）体能状态评分为3分。她的CT扫描显示，一些腹部淋巴结肿大，肝脏有许多转移灶，占据了大部分肝脏。我们根据小细胞肺癌的治疗方案，开始用顺铂和伊立替康进行化疗。考虑到她的体能状态较差，在第一个化疗疗程中，两种药物均以30mg/m²的剂量，每4周给药两次。她的厌食和腹痛立即消失，CT扫描显示所有转移灶大小均缩小。然而，4个疗程后，一些转移灶大小增大。她在确诊后8个月死亡。肿瘤标志物倍增时间为17天。
