Lidsky T I, Manetto C, Ehrich M
Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg 24061.
J Toxicol Environ Health. 1990;29(1):65-75. doi: 10.1080/15287399009531372.
Clinical signs of delayed neuropathy were induced in adult white leghorn chickens given the organophosphorus ester phenyl saligenin phosphate (PSP, 2.5 mg/kg im) 22-24 d before assessment of nerve conduction parameters. Damage to the myelinated sensory portion of the sciatic nerve was indicated by abnormal compound action potentials in treated chickens. In particular, the amplitude of the A beta response was markedly reduced. In addition, the A beta fibers did not respond normally to increasing stimulation intensity. These parameters were more like controls in chickens that had been given PSP and 30 ppm corticosterone for 11 d, beginning 1 d before PSP administration. These studies indicated that nerve conduction parameters could distinguish peripheral nerve damage in chickens given PSP and improvement could be noted in chickens treated with corticosterone.
在评估神经传导参数前22 - 24天，给成年白来航鸡注射有机磷酸酯苯基水杨苷磷酸酯（PSP，2.5毫克/千克，肌肉注射），诱发迟发性神经病的临床体征。治疗组鸡的复合动作电位异常表明坐骨神经有髓感觉部分受损。特别是，Aβ反应的幅度明显降低。此外，Aβ纤维对刺激强度增加的反应不正常。在注射PSP前1天开始，给鸡注射PSP和30 ppm皮质酮，持续11天，这些鸡的这些参数更接近对照组。这些研究表明，神经传导参数可以区分注射PSP的鸡的周围神经损伤，并且在用皮质酮治疗的鸡中可以观察到改善。
