1College of Nursing, Seoul National University, Seoul, Korea.
Biol Res Nurs. 2013 Oct;15(4):459-64. doi: 10.1177/1099800412459882. Epub 2012 Sep 19.
The purpose of this study was to examine the effect of short-term (7 days) undernutrition on Type I (soleus) and Type II (plantaris, gastrocnemius) muscles in rats. Male Sprague-Dawley rats (N = 20) were randomly assigned to one of two groups: a control group (n = 10) in which animals were allowed to have water and pellets ad libitum and an undernourished group (n = 10) in which animals were allowed to have 37% of the total food intake of the control group and water ad libitum. Body weight and food intake were measured daily. After 7 days, rats were anesthetized and the soleus, plantaris, and gastrocnemius muscles and liver were dissected. Body weight, liver weight, muscle weight, Types I and II fiber cross-sectional area, and myofibrillar protein content were determined. After 7 days of undernutrition, the undernourished group showed significant decreases (p < .05) compared to the control group in body weight, liver weight, muscle weight of soleus, plantaris, and gastrocnemius muscles, and cross-sectional areas of Types I and II fiber of the plantaris and gastrocnemius muscles.
本研究旨在探讨短期（7 天）营养不良对大鼠 I 型（比目鱼肌）和 II 型（趾长伸肌、腓肠肌）肌肉的影响。雄性 Sprague-Dawley 大鼠（N=20）被随机分为两组：对照组（n=10），动物可自由饮水和进食颗粒饲料；营养不良组（n=10），动物可自由饮水，进食量为对照组的 37%。每日测量体重和食物摄入量。7 天后，大鼠麻醉，分离比目鱼肌、趾长伸肌和腓肠肌以及肝脏。测定体重、肝重、比目鱼肌、趾长伸肌和腓肠肌的肌肉重量、I 型和 II 型纤维横截面积以及肌原纤维蛋白含量。与对照组相比，营养不良组在 7 天的营养不良后体重、肝重、比目鱼肌、趾长伸肌和腓肠肌的肌肉重量以及趾长伸肌和腓肠肌的 I 型和 II 型纤维横截面积显著降低（p<.05）。
