• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

花生四烯酸衍生物及其在周围神经变性和再生中的作用。

Arachidonic acid derivatives and their role in peripheral nerve degeneration and regeneration.

作者信息

Camara-Lemarroy Carlos Rodrigo, Gonzalez-Moreno Emmanuel Irineo, Guzman-de la Garza Francisco Javier, Fernandez-Garza Nancy Esthela

机构信息

Departamento de Medicina Interna, Hospital Universitario "José Eleuterio González", Universidad Autónoma de Nuevo León, School of Medicine, Colonia Mitras Centro, 64460 Monterrey, Nuevo León, Mexico.

出版信息

ScientificWorldJournal. 2012;2012:168953. doi: 10.1100/2012/168953. Epub 2012 Sep 10.

DOI:10.1100/2012/168953
PMID:22997489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3446639/
Abstract

After peripheral nerve injury, a process of axonal degradation, debris clearance, and subsequent regeneration is initiated by complex local signaling, called Wallerian degeneration (WD). This process is in part mediated by neuroglia as well as infiltrating inflammatory cells and regulated by inflammatory mediators such as cytokines, chemokines, and the activation of transcription factors also related to the inflammatory response. Part of this neuroimmune signaling is mediated by the innate immune system, including arachidonic acid (AA) derivatives such as prostaglandins and leukotrienes. The enzymes responsible for their production, cyclooxygenases and lipooxygenases, also participate in nerve degeneration and regeneration. The interactions between signals for nerve regeneration and neuroinflammation go all the way down to the molecular level. In this paper, we discuss the role that AA derivatives might play during WD and nerve regeneration, and the therapeutic possibilities that arise.

摘要

周围神经损伤后，轴突降解、碎片清除以及随后的再生过程由复杂的局部信号启动，这一过程称为沃勒变性（WD）。此过程部分由神经胶质细胞以及浸润的炎症细胞介导，并受细胞因子、趋化因子等炎症介质以及与炎症反应相关的转录因子激活的调节。这种神经免疫信号的一部分由先天免疫系统介导，包括花生四烯酸（AA）衍生物，如前列腺素和白三烯。负责其产生的酶，即环氧化酶和脂氧合酶，也参与神经变性和再生。神经再生信号与神经炎症之间的相互作用一直延伸到分子水平。在本文中，我们讨论了AA衍生物在沃勒变性和神经再生过程中可能发挥的作用，以及由此产生的治疗可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0438/3446639/a48b92825b2d/TSWJ2012-168953.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0438/3446639/a48b92825b2d/TSWJ2012-168953.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0438/3446639/a48b92825b2d/TSWJ2012-168953.001.jpg

相似文献

1
Arachidonic acid derivatives and their role in peripheral nerve degeneration and regeneration.花生四烯酸衍生物及其在周围神经变性和再生中的作用。
ScientificWorldJournal. 2012;2012:168953. doi: 10.1100/2012/168953. Epub 2012 Sep 10.
2
Role of inflammation and cytokines in peripheral nerve regeneration.炎症和细胞因子在外周神经再生中的作用。
Int Rev Neurobiol. 2013;108:173-206. doi: 10.1016/B978-0-12-410499-0.00007-1.
3
Molecular inflammatory mediators in peripheral nerve degeneration and regeneration.外周神经退变与再生中的分子炎症介质
Neuroimmunomodulation. 2010;17(5):314-24. doi: 10.1159/000292020. Epub 2010 Apr 17.
4
Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction.Wallerian 变性和周围神经状况，既能促进轴突再生，也能诱发神经性疼痛。
Ann Anat. 2011 Jul;193(4):267-75. doi: 10.1016/j.aanat.2011.02.011. Epub 2011 Mar 10.
5
Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration.在沃勒变性的周围神经损伤模型中，中性粒细胞对髓鞘清除至关重要。
J Neurosci. 2017 Oct 25;37(43):10258-10277. doi: 10.1523/JNEUROSCI.2085-17.2017. Epub 2017 Sep 14.
6
ATP release through lysosomal exocytosis from peripheral nerves: the effect of lysosomal exocytosis on peripheral nerve degeneration and regeneration after nerve injury.通过外周神经溶酶体胞吐作用释放三磷酸腺苷：溶酶体胞吐作用对神经损伤后外周神经变性和再生的影响。
Biomed Res Int. 2014;2014:936891. doi: 10.1155/2014/936891. Epub 2014 Jun 30.
7
Granulocyte-macrophage colony-stimulating factor improves mouse peripheral nerve regeneration following sciatic nerve crush.粒细胞-巨噬细胞集落刺激因子促进小鼠坐骨神经挤压后外周神经再生。
Eur J Neurosci. 2018 Sep;48(5):2152-2164. doi: 10.1111/ejn.14106. Epub 2018 Aug 29.
8
Thrombomodulin facilitates peripheral nerve regeneration through regulating M1/M2 switching.血栓调节蛋白通过调节 M1/M2 转换促进周围神经再生。
J Neuroinflammation. 2020 Aug 14;17(1):240. doi: 10.1186/s12974-020-01897-z.
9
Minocycline protects Schwann cells from ischemia-like injury and promotes axonal outgrowth in bioartificial nerve grafts lacking Wallerian degeneration.米诺环素可保护雪旺细胞免受缺血样损伤，并促进缺乏华勒变性的生物人工神经移植物中的轴突生长。
Exp Neurol. 2008 Jul;212(1):189-200. doi: 10.1016/j.expneurol.2008.03.028. Epub 2008 Apr 15.
10
Lipid mediators in inflammatory disorders.炎症性疾病中的脂质介质。
Drugs. 1998 Apr;55(4):487-96. doi: 10.2165/00003495-199855040-00001.

引用本文的文献

1
Bioinformatics Analysis of Differentially Expressed Genes in Carpal Tunnel Syndrome Using RNA Sequencing.基于RNA测序的腕管综合征差异表达基因的生物信息学分析
Iran J Public Health. 2024 Aug;53(8):1871-1882. doi: 10.18502/ijph.v53i8.16293.
2
Endothelial nitric oxide synthase Asp298Glu (894G/T) gene polymorphism as a possible risk factor for the coronary slow flow phenomenon among Iranians.内皮型一氧化氮合酶 Asp298Glu（894G/T）基因多态性可能是伊朗人心血管慢流现象的一个危险因素。
BMC Cardiovasc Disord. 2022 Jun 30;22(1):300. doi: 10.1186/s12872-022-02736-0.
3
Lipids in Pathophysiology and Development of the Membrane Lipid Therapy: New Bioactive Lipids.

本文引用的文献

1
Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia.药物抑制 Akt 和下游信号通路可调节激活的小胶质细胞中环氧化酶-2（COX-2）和前列腺素 E2 合酶-1（mPGES-1）的表达。
J Neuroinflammation. 2012 Jan 3;9:2. doi: 10.1186/1742-2094-9-2.
2
The nuclear events guiding successful nerve regeneration.引导成功神经再生的核事件。
Front Mol Neurosci. 2011 Dec 12;4:53. doi: 10.3389/fnmol.2011.00053. eCollection 2011.
3
Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells.
膜脂质疗法病理生理学与发展中的脂质：新型生物活性脂质
Membranes (Basel). 2021 Nov 24;11(12):919. doi: 10.3390/membranes11120919.
4
Increased TRPV4 expression in non-myelinating Schwann cells is associated with demyelination after sciatic nerve injury.非髓鞘形成雪旺细胞中TRPV4表达增加与坐骨神经损伤后的脱髓鞘有关。
Commun Biol. 2020 Nov 27;3(1):716. doi: 10.1038/s42003-020-01444-9.
5
Transcriptomics Analysis of Porcine Caudal Dorsal Root Ganglia in Tail Amputated Pigs Shows Long-Term Effects on Many Pain-Associated Genes.猪尾巴截肢后猪尾背根神经节的转录组学分析显示对许多疼痛相关基因有长期影响。
Front Vet Sci. 2019 Sep 18;6:314. doi: 10.3389/fvets.2019.00314. eCollection 2019.
6
Inflammation markers in the saliva of infants born from Zika-infected mothers: exploring potential mechanisms of microcephaly during fetal development.寨卡病毒感染母亲所生婴儿唾液中的炎症标志物：探究胎儿发育期间小头畸形的潜在机制。
Sci Rep. 2019 Sep 20;9(1):13606. doi: 10.1038/s41598-019-49796-5.
7
Altered Lipid Metabolism in Blood Mononuclear Cells of Psoriatic Patients Indicates Differential Changes in Psoriasis Vulgaris and Psoriatic Arthritis.银屑病患者血液单核细胞中的脂质代谢改变表明寻常型银屑病和银屑病关节炎的差异变化。
Int J Mol Sci. 2019 Aug 30;20(17):4249. doi: 10.3390/ijms20174249.
8
The neurochemistry of peripheral nerve regeneration.周围神经再生的神经化学
Indian J Plast Surg. 2017 Jan-Apr;50(1):5-15. doi: 10.4103/ijps.IJPS_14_17.
9
Successful reduction of inflammatory responses and arachidonic acid-cyclooxygenase 2 pathway in human pulmonary artery endothelial cells by silencing adipocyte fatty acid-binding protein.通过沉默脂肪细胞脂肪酸结合蛋白成功降低人肺动脉内皮细胞中的炎症反应和花生四烯酸-环氧化酶2途径。
J Inflamm (Lond). 2017 Mar 20;14:8. doi: 10.1186/s12950-017-0155-6. eCollection 2017.
10
Increased arachidonic acid-containing phosphatidylcholine is associated with reactive microglia and astrocytes in the spinal cord after peripheral nerve injury.外周神经损伤后，脊髓中含花生四烯酸的磷脂酰胆碱增加与反应性小胶质细胞和星形胶质细胞有关。
Sci Rep. 2016 May 23;6:26427. doi: 10.1038/srep26427.
通过 EP1 和 EP3 受体阻断前列腺素 E2 信号转导可减弱 Flt3L 依赖性造血祖细胞向树突状细胞的发育。
Blood. 2012 Feb 16;119(7):1671-82. doi: 10.1182/blood-2011-03-342428. Epub 2011 Nov 22.
4
Leukotrienes in nociceptive pathway and neuropathic/inflammatory pain.白细胞三烯在伤害感受通路和神经病理性/炎性疼痛中的作用。
Biol Pharm Bull. 2011;34(8):1163-9. doi: 10.1248/bpb.34.1163.
5
Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction.Wallerian 变性和周围神经状况，既能促进轴突再生，也能诱发神经性疼痛。
Ann Anat. 2011 Jul;193(4):267-75. doi: 10.1016/j.aanat.2011.02.011. Epub 2011 Mar 10.
6
Role of prostaglandin E2 in the synthesis of the pro-inflammatory cytokine interleukin-6 in primary sensory neurons: an in vivo and in vitro study.前列腺素 E2 在原代感觉神经元中促炎细胞因子白细胞介素-6 合成中的作用：一项体内和体外研究。
J Neurochem. 2011 Sep;118(5):841-54. doi: 10.1111/j.1471-4159.2011.07230.x. Epub 2011 Mar 28.
7
Expression and detrimental role of hematopoietic prostaglandin D synthase in spinal cord contusion injury.表达和促血细胞生成素 D 合酶在脊髓挫伤损伤中的有害作用。
Glia. 2011 Apr;59(4):603-14. doi: 10.1002/glia.21128. Epub 2011 Feb 3.
8
Latanoprost promotes neurite outgrowth in differentiated RGC-5 cells via the PI3K-Akt-mTOR signaling pathway.拉坦前列素通过 PI3K-Akt-mTOR 信号通路促进分化的 RGC-5 细胞的神经突生长。
Cell Mol Neurobiol. 2011 May;31(4):597-604. doi: 10.1007/s10571-011-9653-x. Epub 2011 Jan 29.
9
The prostaglandin E2 receptor, EP2, regulates survivin expression via an EGFR/STAT3 pathway in UVB-exposed mouse skin.前列腺素 E2 受体 EP2 通过 EGFR/STAT3 通路调节 UVB 暴露小鼠皮肤中的生存素表达。
Mol Carcinog. 2011 Jun;50(6):439-48. doi: 10.1002/mc.20728. Epub 2011 Jan 25.
10
A novel role of prostaglandin E2 in neuropathic pain: blockade of microglial migration in the spinal cord.前列腺素 E2 在神经病理性疼痛中的新作用：阻断脊髓中小胶质细胞的迁移。
Glia. 2011 Feb;59(2):208-18. doi: 10.1002/glia.21090.