Department of Dermatology, Etimesgut State Hospital, Ankara, Turkey.
Int J Dermatol. 2013 Mar;52(3):371-6. doi: 10.1111/j.1365-4632.2012.05691.x. Epub 2012 Sep 24.
Isotretinoin is the most efficacious long-lasting treatment for acne; however, some factors, including polycystic ovary syndrome (PCOS), patient age, family history, and type and number of acne lesions, may lead to treatment resistance or relapse following treatment. The aim of this study was to compare the efficacy and permanence of systemic isotretinoin (SI) in nodulocystic acne patients with and without PCOS and to evaluate the factors associated with relapse during the first and second post-treatment years.
The study included 96 female patients with nodulocystic acne. SI 0.5-1 mg/kg/dl was given, with a total cumulative dose of 120-150 mg/kg. Response to treatment and relapse during the first and second post-treatment years were evaluated.
In all, the 50 non-PCOS and 46 PCOS acne patients were similar. SI was similarly efficacious in both groups. In total, eight patients relapsed during the first post-treatment year, versus 16 during the second. Relapse during the first year was associated with the number of nodules at the start of treatment and the number of papulopustular lesions at the end of treatment, whereas PCOS, patient age, and the number of nodules at the start of treatment were associated relapse during the second year.
Regardless of its association with PCOS, SI was effective in the treatment of nodulocystic acne. The factors associated with relapse during the 1(st) and 2(nd) post-treatment years differed, except for the number of nodules at the start of treatment.
异维 A 酸是治疗痤疮最有效的长期治疗方法；然而，一些因素，包括多囊卵巢综合征（PCOS）、患者年龄、家族史以及痤疮病变的类型和数量，可能导致治疗抵抗或治疗后复发。本研究旨在比较伴有和不伴有 PCOS 的结节囊肿性痤疮患者全身用异维 A 酸（SI）的疗效和持久性，并评估治疗后第 1 年和第 2 年复发的相关因素。
该研究纳入了 96 例女性结节囊肿性痤疮患者。给予异维 A 酸 0.5-1mg/kg/dl，总累积剂量为 120-150mg/kg。评估治疗反应和治疗后第 1 年和第 2 年的复发情况。
共 50 例非 PCOS 痤疮患者和 46 例 PCOS 痤疮患者相似。两组 SI 疗效相似。共有 8 例患者在治疗后第 1 年复发，16 例患者在第 2 年复发。第 1 年复发与治疗开始时的结节数量和治疗结束时的丘疹脓疱性病变数量有关，而 PCOS、患者年龄和治疗开始时的结节数量与第 2 年的复发有关。
无论是否与 PCOS 相关，SI 对结节囊肿性痤疮的治疗均有效。治疗后第 1 年和第 2 年复发的相关因素不同，除了治疗开始时的结节数量。
