Department of Periodontology, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkey.
Oral Dis. 2013 May;19(4):394-400. doi: 10.1111/odi.12017. Epub 2012 Sep 24.
This observational prospective cohort study aimed to evaluate the effects of non-surgical periodontal treatment on clinical periodontal measurements and systemic inflammatory mediator levels in low or moderate to highly active rheumatoid arthritis (RA) patients with chronic periodontitis.
Rheumatoid arthritis activity was assessed with disease activity score test (DAS28). Thirty patients with RA with moderate to high disease activity (DAS28 ≥ 3.2) and chronic periodontitis (MHDA group) and thirty patients with RA with low disease activity (DAS28 < 3.2) and chronic periodontitis (LDA group) were enrolled in the study. The patients were monitored at the beginning and 3 months after undergoing periodontal therapy. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-α) levels in serum, DAS28 and periodontal parameters were evaluated.
Erythrocyte sedimentation rate, CRP, TNF-α levels in serum, DAS28 and periodontal parameters exhibited similar and significant reduction 3 months after the non-surgical periodontal treatment.
Non-surgical periodontal treatment may prove beneficial in reducing RA severity as measured by ESR, CRP, TNF-α levels in serum and DAS28 in low or moderate to highly active RA patients with chronic periodontitis.
本观察性前瞻性队列研究旨在评估非手术牙周治疗对慢性牙周炎中低或中高度活动类风湿关节炎（RA）患者的临床牙周测量值和全身炎症介质水平的影响。
使用疾病活动评分测试（DAS28）评估 RA 活动度。将 30 名具有中高度疾病活动度（DAS28≥3.2）和慢性牙周炎的 RA 患者（MHDA 组）和 30 名具有低疾病活动度（DAS28<3.2）和慢性牙周炎的 RA 患者（LDA 组）纳入研究。在牙周治疗前和治疗后 3 个月对患者进行监测。评估血清红细胞沉降率（ESR）、C 反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）水平、DAS28 和牙周参数。
非手术牙周治疗 3 个月后，血清 ESR、CRP、TNF-α 水平、DAS28 和牙周参数均显著降低。
非手术牙周治疗可能有助于降低慢性牙周炎中低或中高度活动 RA 患者的 RA 严重程度，通过 ESR、CRP、TNF-α 水平和 DAS28 来衡量。
