衰老：对离体大鼠心房中毒蕈碱激动剂变时作用的影响。

Aging: effects on chronotropic actions of muscarinic agonists in isolated rat atria.

作者信息

Kennedy R H, Seifen E

机构信息

Department of Pharmacology and Interdisciplinary Toxicology, University of Arkansas for Medical Sciences, Little Rock 72205.

出版信息

Mech Ageing Dev. 1990 Jan;51(1):81-7. doi: 10.1016/0047-6374(90)90164-b.

DOI:10.1016/0047-6374(90)90164-b

PMID:2299892

Abstract

Negative chronotropic effects of acetylcholine and carbachol were compared in right atria isolated from adult and aged Fischer 344 rats. Preparations from aged rats were more sensitive to the action of acetylcholine; however, there was no difference in responsiveness to carbachol or to acetylcholine after pretreatment with diisopropylfluorophosphate, an irreversible cholinesterase inhibitor. These data suggest that the enhanced sensitivity to the direct chronotropic action of acetylcholine is the result of aging-related reductions in acetylcholinesterase activity.

摘要

比较了乙酰胆碱和卡巴胆碱对成年和老年Fischer 344大鼠离体右心房的负性变时作用。老年大鼠的标本对乙酰胆碱的作用更敏感；然而，在用不可逆胆碱酯酶抑制剂二异丙基氟磷酸预处理后，对卡巴胆碱或乙酰胆碱的反应性没有差异。这些数据表明，对乙酰胆碱直接变时作用的敏感性增强是与衰老相关的乙酰胆碱酯酶活性降低的结果。