Epidemiology & Disease Control Division, Ministry of Health, Singapore, College of Medicine Building, Singapore.
Epidemiol Infect. 2013 Aug;141(8):1721-30. doi: 10.1017/S0950268812002130. Epub 2012 Sep 24.
We undertook a national paediatric seroprevalence survey of measles, mumps and rubella (MMR) in Singapore to assess the impact of the national childhood immunization programme against these three diseases after introduction of the trivalent MMR vaccine in 1990. The survey involved 1200 residual sera of Singapore residents aged 1-17 years collected from two hospitals between 2008 and 2010. The overall prevalence of antibodies against measles, mumps and rubella was 83∙1% [95% confidence interval (CI) 80∙9-85∙1], 71.8% (95% CI 69∙1-74∙2) and 88∙5% (95% CI 86∙6-90∙2), respectively. For all three diseases, the lowest prevalence was in children aged 1 year (47∙8-62∙3%). The seroprevalence of the vaccinated children declined over time. The national MMR immunization programme is effective in raising the herd immunity of the childhood population, although certain age groups are more susceptible to infection, in particular, those who are not eligible for vaccination at age <15 months.
我们在新加坡进行了一项全国性儿科麻疹、腮腺炎和风疹（MMR）血清流行率调查，以评估自 1990 年引入三价 MMR 疫苗以来，针对这三种疾病的国家儿童免疫计划的影响。该调查涉及 2008 年至 2010 年期间从两家医院采集的 1200 名 1-17 岁新加坡居民的剩余血清。麻疹、腮腺炎和风疹抗体的总流行率分别为 83.1%（95%置信区间 80.9-85.1）、71.8%（95%置信区间 69.1-74.2）和 88.5%（95%置信区间 86.6-90.2）。对于所有三种疾病，1 岁儿童的流行率最低（47.8-62.3%）。随着时间的推移，接种疫苗儿童的血清阳性率下降。尽管某些年龄组更容易感染，特别是那些在 15 个月以下不符合接种条件的儿童，但国家 MMR 免疫计划有效地提高了儿童人群的群体免疫力。
