Department of Orthopeadics, Tianjin Hospital, Tianjin Medical University, Tianjin, China.
Leuk Res. 2013 Jan;37(1):50-7. doi: 10.1016/j.leukres.2012.08.027. Epub 2012 Sep 20.
Results of available literatures, which concerned the association between TNF-α promoter -238/-308 gene polymorphisms and multiple myeloma (MM), are of great controversy. A review was performed in studies reporting on the association between them. Odds ratios (ORs) with 95% confidence interval (CI) were used to evaluate the association. The pooled ORs indicated that there was no association between TNF-α -238/-308 polymorphisms and MM susceptibility in overall population. Sub-group analysis also confirmed that no evidence supported the relevance of TNF-α promoter -238/-308 gene polymorphisms with MM. Studies with large sample size and multi-ethnics may be needed to further explore the association between them.
现有文献研究结果表明，肿瘤坏死因子-α 启动子-238/-308 基因多态性与多发性骨髓瘤（MM）之间存在关联，但存在较大争议。本研究对相关文献进行了综述。采用比值比（OR）及其 95%置信区间（CI）来评估关联。汇总 OR 表明，TNF-α-238/-308 多态性与总体人群 MM 易感性之间无关联。亚组分析也证实，TNF-α 启动子-238/-308 基因多态性与 MM 无相关性。可能需要进行更大样本量和多民族的研究来进一步探讨它们之间的关系。
