Department of Pathology, University of Chicago, Chicago, IL 60637, USA.
Trends Immunol. 2013 Jan;34(1):33-40. doi: 10.1016/j.it.2012.08.005. Epub 2012 Sep 19.
Due to the critical role of forkhead box (Fox)p3(+) regulatory T cells (Tregs) in the regulation of immunity and the enrichment of Tregs within many human tumors, several emerging therapeutic strategies for cancer involve the depletion or modulation of Tregs, with the aim of eliciting enhanced antitumor immune responses. Here, we review recent advances in understanding of the fundamental biology of Tregs, and discuss the implications of these findings for current models of tumor-associated Treg biology. In particular, we discuss the context-dependent functional diversity of Tregs, the developmental origins of these cells, and the nature of the antigens that they recognize within the tumor environment. In addition, we highlight critical areas of focus for future research.
由于叉头框（Fox)p3(+)调节性 T 细胞（Tregs）在免疫调节中的关键作用，以及 Tregs 在许多人类肿瘤中的富集，一些新出现的癌症治疗策略涉及 Tregs 的耗竭或调节，目的是引发增强的抗肿瘤免疫反应。在这里，我们回顾了对 Tregs 基础生物学的最新理解进展，并讨论了这些发现对当前肿瘤相关 Treg 生物学模型的意义。特别是，我们讨论了 Tregs 的功能多样性、这些细胞的发育起源以及它们在肿瘤环境中识别的抗原的性质。此外，我们强调了未来研究的重点领域。
