State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University-Peking University Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Exp Cell Res. 2013 Jan 15;319(2):142-6. doi: 10.1016/j.yexcr.2012.09.004. Epub 2012 Sep 19.
Autophagy is an evolutionarily conserved lysosome-dependent degradation pathway. In recent years, many important advances have been made in understanding the cellular and molecular mechanism of autophagosome formation. However, the late stages of autophagy-the cellular events after formation of the autolysosome-are relatively rarely studied. In this review, we discussed the cellular process and molecular mechanism of autophagic lysosome reformation, a cellular events which defines the terminal stage of autophagy.
自噬是一种进化上保守的溶酶体依赖性降解途径。近年来，人们在理解自噬体形成的细胞和分子机制方面取得了许多重要进展。然而，自噬的晚期阶段——即自噬溶酶体形成后的细胞事件——相对较少被研究。在这篇综述中，我们讨论了自噬溶酶体再形成的细胞过程和分子机制，这一细胞事件定义了自噬的终末阶段。
