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基层医疗中心血管疾病预防的挑战:一项针对8928名不同风险水平患者的欧洲观察性研究的启示

The challenge of cardiovascular prevention in primary care: implications of a European observational study in 8928 patients at different risk levels.

作者信息

Ludt Sabine, Wensing Michel, Campbell Stephen M, Ose Dominik, van Lieshout Jan, Rochon Justine, Uhlmann Lorenz, Szecsenyi Joachim

机构信息

University Hospital of Heidelberg, Heidelberg, Germany.

出版信息

Eur J Prev Cardiol. 2014 Feb;21(2):203-13. doi: 10.1177/2047487312462798. Epub 2012 Sep 21.

Abstract

BACKGROUND

Cardiovascular prevention can be provided to patients at different risk levels. The aim of this study was to compare the quality of cardiovascular prevention provided in European primary care between patients with diagnosed coronary heart disease (CHD) and individuals at high risk due to known risk factors but not labelled with a diagnosis of cardiovascular disease (CVD). Additionally, we aimed to identify individual and practice factors to predict risk factor control.

METHODS

An international cross-sectional study was conducted in 10 European countries. Clinical record data were abstracted for quality indicators for 8928 patients in 10 countries and patient questionnaires were completed by 7846 patients in nine countries. Information about 320 general practices was assessed using practice questionnaires and interviews. Hierarchical multilevel modelling was used for analyses.

RESULTS

Recording of risk factors and advice was higher in the CHD than in the high-risk group. Risk factor control was better in the CHD group: uncontrolled levels of blood pressure (34.2 vs. 49.3%; p < 0.001), cholesterol (32.4 vs. 64.5%; p < 0.001). Predictors of risk factor control were medication adherence (RR 0.97; p = 0.007) and health-related quality of life (RR 0.86; p = 0.005). Being at high risk (RR 1.42; p < 0.001), being single (RR 1.12; p < 0.001), and having lower educational level (RR 1.09; p < 0.001) were associated with poorer risk factor control. Practice factors were not associated with outcomes.

CONCLUSIONS

Strategies to improve guidelines adherence in cardiovascular prevention may be stronger focused on individuals at risk before CVD is diagnosed and require organizational and political support to reinforce general practices.

摘要

背景

心血管疾病预防可针对不同风险水平的患者提供。本研究的目的是比较欧洲初级保健机构中,已确诊冠心病(CHD)的患者与因已知风险因素而处于高风险但未被诊断为心血管疾病(CVD)的个体之间心血管疾病预防的质量。此外,我们旨在确定预测风险因素控制的个体因素和医疗实践因素。

方法

在10个欧洲国家进行了一项国际横断面研究。提取了10个国家8928例患者的临床记录数据作为质量指标,并由9个国家的7846例患者完成了患者问卷。通过医疗实践问卷和访谈评估了320家普通医疗机构的信息。采用分层多级模型进行分析。

结果

冠心病患者的风险因素记录和建议比高风险组更高。冠心病组的风险因素控制更好:血压未控制水平(34.2%对49.3%;p<0.001),胆固醇(32.4%对64.5%;p<0.001)。风险因素控制的预测因素是药物依从性(RR 0.97;p=0.007)和健康相关生活质量(RR 0.86;p=0.005)。处于高风险(RR 1.42;p<0.001)、单身(RR 1.12;p<0.001)和教育水平较低(RR 1.09;p<0.001)与较差的风险因素控制相关。医疗实践因素与结果无关。

结论

改善心血管疾病预防指南依从性的策略可能更应侧重于在心血管疾病诊断前的高危个体,并且需要组织和政策支持以加强普通医疗机构的工作。

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