Emmenegger H, Cerletti A
Agents Actions. 1977 Sep;7(3):391-7. doi: 10.1007/BF01969573.
A model consisting of a cat head perfused in isolation with the animal's own blood is described. The use of endogenous blood allows the organ to function under physiological conditions for several hours. The blood is taken from the abdominal aorta of the anaesthetized animal and passed to the carotid arteries via an extracorporeal circulation system. The perfusion pressure can be varied at will and is regulated electronically. The volume of blood in the extracorporeal circulation system is only 6 ml. The tests performed on this model were designed to study the behaviour of the cortical EEG and the cortical micro flow. Neither of these parameters underwent any change after institution of the artificial perfusion, and the blood gases also remained fairly stable. The model is suitable for studying both physiological and pharmacological problems.
本文描述了一种模型，该模型是一个单独灌注动物自身血液的猫头。使用内源性血液可使该器官在生理条件下运行数小时。血液取自麻醉动物的腹主动脉，并通过体外循环系统输送至颈动脉。灌注压力可随意改变，并通过电子方式调节。体外循环系统中的血液量仅为6毫升。在此模型上进行的测试旨在研究皮层脑电图和皮层微血流的行为。在进行人工灌注后，这两个参数均未发生任何变化，并且血气也保持相当稳定。该模型适用于研究生理和药理问题。
