State Key Laboratory of Veterinary Etiological Biology and National Foot and Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Nanoscale. 2012 Nov 7;4(21):6692-706. doi: 10.1039/c2nr31967e. Epub 2012 Sep 21.
Lanthanide-doped fluorescent materials have gained increasing attention in recent years due to their unique luminescence properties which have led to their use in wide-ranging fields including those of biological applications. Aside from being used as agents for in vivo imaging, lanthanide-doped fluorescent materials also present many advantages for use in bioassays and therapy. In this review, we summarize the applications of lanthanide-doped up-converting phosphors (UCPs) in protein and gene detection, as well as in photodynamic and gene therapy in recent years, and outline their future potential in biological applications. The current report could serve as a reference for researchers in relevant fields.
近年来，由于镧系掺杂荧光材料具有独特的发光性能，因此在包括生物应用在内的广泛领域得到了越来越多的关注。除了用作体内成像的试剂外，镧系掺杂荧光材料在生物测定和治疗中也具有许多优势。在这篇综述中，我们总结了近年来镧系掺杂上转换荧光粉（UCPs）在蛋白质和基因检测以及光动力和基因治疗中的应用，并概述了它们在生物应用中的未来潜力。本报告可以为相关领域的研究人员提供参考。
