获得性免疫缺陷病毒感染患者的脂肪分布与脂肪因子的关系。
Relationship of fat distribution with adipokines in patients with acquired immunodeficiency virus infection.
机构信息
Facultad de Medicina, Centro de Investigacion en Endocrinologia y Nutricion Clinica-I.E.N, Unit of Investigation Hospital Universitario Rio Hortega, Valladolid, Spain.
出版信息
J Clin Lab Anal. 2012 Sep;26(5):336-41. doi: 10.1002/jcla.21528.
BACKGROUND
The aim was to examine the relationship of fat distributions with adipokines concentrations in HIV-infected patients.
METHODS
This was a cross-sectional analysis of 36 HIV (free of lipodystrophy) infected patients. Dual-energy X-ray absorptiometry was used.
RESULTS
In the multivariate analysis, basal adiponectin concentration was a dependent variable, whereas waist to hip ratio and abdominal fat mass were independent predictors in the model (F = 5.1; P < 0.05). Adiponectin concentration decreases by 5.541.2 μg/ml (CI 95%: 8,071.9-3,029.1) for each unit of waist to hip ratio and 561.9 ng/ml (CI 95%: 918.2-213.4) for each kilogram of fat mass of abdominal area. In the multivariate analysis, basal leptin concentration was a dependent variable, whereas waist circumference remained an independent predictor in the model (F = 6.3; P < 0.05), with a direct correlation. Leptin concentration increases by 0.067 ng/ml (CI 95%: 0.001-0.12) for each centimeter of waist circumference.
CONCLUSIONS
Leptin and adiponectin are related with adiposity in HIV-infected patients.
背景
本研究旨在探讨 HIV 感染患者脂肪分布与脂肪因子浓度的关系。
方法
这是一项横断面分析，共纳入 36 例（无脂肪营养不良）HIV 感染患者。采用双能 X 射线吸收法。
结果
在多变量分析中，基础脂联素浓度是因变量，而腰围臀围比和腹部脂肪量是模型中的独立预测因子（F = 5.1；P < 0.05）。脂联素浓度每降低 5.541.2 μg/ml（95%CI：8，071.9-3，029.1），腰围臀围比增加 1 个单位；腹部脂肪量每增加 1 公斤，脂联素浓度降低 561.9 ng/ml（95%CI：918.2-213.4）。在多变量分析中，基础瘦素浓度是因变量，而腰围仍然是模型中的独立预测因子（F = 6.3；P < 0.05），呈正相关。腰围每增加 1 厘米，瘦素浓度增加 0.067 ng/ml（95%CI：0.001-0.12）。
结论
瘦素和脂联素与 HIV 感染患者的肥胖有关。
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