Wu Bin, Fukuo Keisuke, Suzuki Kazuhisa, Yoshino Gen, Kazumi Tsutomu
Open Research Center for Studying of Lifestyle-Related Diseases, Mukogawa Women's University, Nishinomiya, Hyogo, Japan.
Endocr J. 2009;56(6):773-82. doi: 10.1507/endocrj.k08e-332. Epub 2009 Jun 9.
Obesity and systemic oxidative stress are closely related. However data concerning the relationships between oxidative stress and body fat mass distribution are sparse. Anthropometric and metabolic profile was evaluated in 148 clinically healthy middle-aged women to assess the correlations between oxidative stress, fat mass distribution, adipokines, and inflammatory markers. Systemic oxidative stress was assessed by urinary creatinine-indexed 8-epi-prostaglandin F-(2alpha) (8-epi-PGF(2alpha)). Body fat mass distribution was examined by dual-energy X-ray absorptiometry (DXA). Lipid profile, adipokines and inflammatory markers including leptin, adiponectin, high sensitive C-reactive protein (hsCRP), plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-alpha (TNF-alpha) were determined. We found body mass index (BMI), waist circumference (WC), both central and peripheral DXA-derived regional fat mass (FM) accumulations were positively correlated with 8-epi-PGF(2alpha). Leptin, hsCRP and PAI-1also positively associated with 8-epi-PGF(2alpha). After adjustment for BMI and WC, lower-body FM, total FM and PAI-1 retained significant association with 8-epi-PGF(2alpha). Mutliple linear regression analyses indicated lower-body FM and PAI-1 were the two important predicators of 8-epi-PGF(2alpha). These results suggest that DXA-derived regional FM indices, especially low extremity adiposity, are more closely associated with systemic oxidative stress than indirect anthropometric indices. Positive associations between 8-epi-PGF(2alpha) and PAI-1, hsCRP, leptin support the notion that oxidative-stress-induced dysregulation of inflammation and adipokines may mediate the obesity-related metabolic derangement.
肥胖与全身氧化应激密切相关。然而，关于氧化应激与体脂分布之间关系的数据却很少。对148名临床健康的中年女性进行了人体测量和代谢状况评估，以评估氧化应激、体脂分布、脂肪因子和炎症标志物之间的相关性。通过尿肌酐校正的8-表-前列腺素F2α（8-epi-PGF2α）评估全身氧化应激。通过双能X线吸收法（DXA）检测体脂分布。测定血脂、脂肪因子和炎症标志物，包括瘦素、脂联素、高敏C反应蛋白（hsCRP）、纤溶酶原激活物抑制剂-1（PAI-1）、肿瘤坏死因子-α（TNF-α）。我们发现体重指数（BMI）、腰围（WC）、DXA得出的中央和外周区域脂肪量（FM）积累均与8-epi-PGF2α呈正相关。瘦素、hsCRP和PAI-1也与8-epi-PGF2α呈正相关。在对BMI和WC进行校正后，下半身FM、总FM和PAI-1与8-epi-PGF2α仍保持显著相关性。多元线性回归分析表明，下半身FM和PAI-1是8-epi-PGF2α的两个重要预测因子。这些结果表明，DXA得出的区域FM指数，尤其是下肢肥胖，比间接人体测量指数与全身氧化应激的关系更为密切。8-epi-PGF2α与PAI-1、hsCRP、瘦素之间的正相关支持了氧化应激诱导的炎症和脂肪因子失调可能介导肥胖相关代谢紊乱的观点。
