Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, PR China.
Chem Asian J. 2012 Dec;7(12):2777-81. doi: 10.1002/asia.201200686. Epub 2012 Sep 24.
It is better to be cooperative: A highly diastereo- and enantioselective asymmetric [3+2] cycloaddition reaction of α-aryl isocyanoacetates with N-aryl maleimides through cooperative catalysis of cinchona alkaloid-derived squaramide/AgSbF(6) was developed. A wide range of optically active, substituted 1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c] pyrrole derivatives was obtained in high yields (up to 98%), high diastereoselectivities (>20:1 d.r.), and good to excellent enantioselectivities (up to 92% ee) under mild reaction conditions.
通过金鸡纳生物碱衍生的手性联萘二胺/AgSbF6 协同催化，开发了一种高非对映选择性和对映选择性的不对称[3+2]环加成反应，用于α-芳基异氰基乙酸酯与 N-芳基马来酰亚胺的反应。在温和的反应条件下，以高产率（高达 98%）、高非对映选择性（>20:1 d.r.）和优异的对映选择性（高达 92%ee）得到了广泛的光学活性、取代的 1,3a,4,5,6,6a-六氢吡咯并[3,4-c]吡咯衍生物。
