HIV 的 T 细胞免疫应答
The T-cell response to HIV.
机构信息
Ragon Institute of MGH, MIT, and Harvard Mass General Hospital-East, Charlestown, Massachusetts 02129, USA.
出版信息
Cold Spring Harb Perspect Med. 2012 Nov 1;2(11):a007054. doi: 10.1101/cshperspect.a007054.
Abstract
HIV is a disease in which the original clinical observations of severe opportunistic infections gave the first clues regarding the underlying pathology, namely that HIV is essentially an infection of the immune system. HIV infects and deletes CD4(+) T cells that normally coordinate the adaptive T- and B-cell response to defend against intracellular pathogens. The immune defect is immediate and profound: At the time of acute infection with an AIDS virus, typically more than half of the gut-associated CD4(+) T cells are depleted, leaving a damaged immune system to contend with a life-long infection.
摘要
HIV 是一种疾病，其中严重机会性感染的最初临床观察为潜在病理学提供了第一个线索，即 HIV 本质上是免疫系统的感染。HIV 感染并删除了正常协调适应性 T 细胞和 B 细胞反应以抵御细胞内病原体的 CD4(+)T 细胞。免疫缺陷是即时且深刻的：在急性感染艾滋病病毒时，通常超过一半的肠道相关 CD4(+)T 细胞被消耗殆尽，留下受损的免疫系统来应对终身感染。
相似文献
1
The T-cell response to HIV.HIV 的 T 细胞免疫应答
Cold Spring Harb Perspect Med. 2012 Nov 1;2(11):a007054. doi: 10.1101/cshperspect.a007054.
2
Aspects of immunopathogenic mechanisms of HIV infection.HIV感染的免疫致病机制方面
SADJ. 2007 Nov;62(10):432-4, 436.
3
CD8+ T-cells: function and response to HIV infection.CD8 + T细胞：功能及对HIV感染的反应
Curr HIV Res. 2004 Jan;2(1):23-37. doi: 10.2174/1570162043485077.
4
Apoptosis of HIV-specific CD8+ T cells: an HIV evasion strategy.HIV特异性CD8 + T细胞凋亡：一种HIV逃逸策略。
Cell Death Differ. 2005 Aug;12 Suppl 1:859-70. doi: 10.1038/sj.cdd.4401595.
5
Acute HIV infection induces mucosal infiltration with CD4+ and CD8+ T cells, epithelial apoptosis, and a mucosal barrier defect.急性 HIV 感染可诱导黏膜中浸润 CD4+和 CD8+T 细胞、上皮细胞凋亡和黏膜屏障缺陷。
Gastroenterology. 2010 Oct;139(4):1289-300. doi: 10.1053/j.gastro.2010.06.065. Epub 2010 Jun 27.
6
Frequent infection of peripheral blood CD8-positive T-lymphocytes with HIV-1. Edinburgh Heterosexual Transmission Study Group.外周血CD8阳性T淋巴细胞频繁感染HIV-1。爱丁堡异性传播研究小组。
Lancet. 1996 Sep 7;348(9028):649-54. doi: 10.1016/s0140-6736(96)02091-0.
7
Fully immunocompetent CD8+ T lymphocytes are present in autologous haematopoietic stem cell transplantation recipients despite an ineffectual T-helper response.尽管T辅助细胞反应无效，但在自体造血干细胞移植受者中仍存在完全免疫活性的CD8 + T淋巴细胞。
PLoS One. 2008;3(10):e3616. doi: 10.1371/journal.pone.0003616. Epub 2008 Oct 31.
8
Massive CD8 T cell response to primary HIV infection in the setting of severe clinical presentation.在严重临床表现背景下，针对原发性HIV感染的大量CD8 T细胞应答。
AIDS Res Hum Retroviruses. 2012 Aug;28(8):789-92. doi: 10.1089/AID.2011.0145.
9
Cellular immune responses to HIV.对HIV的细胞免疫反应。
Nature. 2001 Apr 19;410(6831):980-7. doi: 10.1038/35073658.
10
Cytotoxic CD4 T-cells during HIV infection: Targets or weapons?在 HIV 感染期间的细胞毒性 CD4 T 细胞：是靶标还是武器？
J Clin Virol. 2019 Oct;119:17-23. doi: 10.1016/j.jcv.2019.08.004. Epub 2019 Aug 16.
引用本文的文献
1
CPSF6 promotes HIV-1 preintegration complex function.CPSF6促进HIV-1整合前复合物的功能。
J Virol. 2025 May 20;99(5):e0049025. doi: 10.1128/jvi.00490-25. Epub 2025 Apr 9.
2
Natural Resistance to HIV Infection: Role of Immune Activation.对HIV感染的天然抵抗力：免疫激活的作用。
Immun Inflamm Dis. 2025 Feb;13(2):e70138. doi: 10.1002/iid3.70138.
3
A binary trait model reveals the fitness effects of HIV-1 escape from T cell responses.二元性状模型揭示了HIV-1逃避T细胞反应的适应性影响。
Proc Natl Acad Sci U S A. 2025 Feb 25;122(8):e2405379122. doi: 10.1073/pnas.2405379122. Epub 2025 Feb 19.
4
Cigarette smoke alters circRNA expression in human T-cells.香烟烟雾会改变人类T细胞中的环状RNA表达。
F1000Res. 2025 Apr 9;12:566. doi: 10.12688/f1000research.130430.2. eCollection 2023.
5
Involvement of Human Cellular Proteins and Structures in Realization of the HIV Life Cycle: A Comprehensive Review, 2024.人类细胞蛋白和结构在 HIV 生命周期实现中的作用：全面综述，2024 年。
Viruses. 2024 Oct 29;16(11):1682. doi: 10.3390/v16111682.
6
Evaluation of the mindray CL900i CLIA HIV Ag/Ab combo assay for sensitive and specific HIV screening compared to established methods.评价迈瑞 CL900i CLIA HIV Ag/Ab 联合检测试剂用于敏感和特异性 HIV 筛查的性能，与已建立的方法进行比较。
Sci Rep. 2024 Nov 15;14(1):28177. doi: 10.1038/s41598-024-78271-z.
7
Cyclophilin A facilitates HIV-1 integration.亲环素 A 促进 HIV-1 整合。
J Virol. 2024 Nov 19;98(11):e0094724. doi: 10.1128/jvi.00947-24. Epub 2024 Oct 31.
8
The Intersection of HIV and Pulmonary Vascular Health: From HIV Evolution to Vascular Cell Types to Disease Mechanisms.HIV与肺血管健康的交叉领域：从HIV演变到血管细胞类型再到疾病机制
J Vasc Dis. 2024 Jun;3(2):174-200. doi: 10.3390/jvd3020015. Epub 2024 May 6.
9
Immune perturbation following SHIV infection is greater in newborn macaques than in infants.SHIV 感染后，新生猕猴的免疫紊乱比婴儿更严重。
JCI Insight. 2024 Aug 27;9(19):e144448. doi: 10.1172/jci.insight.144448.
10
Rapid intra-host diversification and evolution of SARS-CoV-2 in advanced HIV infection.在晚期 HIV 感染中，SARS-CoV-2 在宿主内的快速多样化和进化。
Nat Commun. 2024 Aug 22;15(1):7240. doi: 10.1038/s41467-024-51539-8.
本文引用的文献
1
HIV transmission.艾滋病毒传播。
Cold Spring Harb Perspect Med. 2012 Nov 1;2(11):a006965. doi: 10.1101/cshperspect.a006965.
2
Limited immunogenicity of HIV CD8+ T-cell epitopes in acute Clade C virus infection.急性 C 型病毒感染中 HIV CD8+ T 细胞表位的免疫原性有限。
J Infect Dis. 2011 Sep 1;204(5):768-76. doi: 10.1093/infdis/jir394.
3
Coordinate linkage of HIV evolution reveals regions of immunological vulnerability.HIV 进化的坐标连锁揭示了免疫脆弱区域。
Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11530-5. doi: 10.1073/pnas.1105315108. Epub 2011 Jun 20.
4
Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine.效应记忆 T 细胞疫苗对高致病性 SIV 的早期深度控制。
Nature. 2011 May 26;473(7348):523-7. doi: 10.1038/nature10003. Epub 2011 May 11.
5
Differential microRNA regulation of HLA-C expression and its association with HIV control.HLA-C 表达的差异 microRNA 调控及其与 HIV 控制的关联。
Nature. 2011 Apr 28;472(7344):495-8. doi: 10.1038/nature09914. Epub 2011 Apr 17.
6
Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection.急性 HIV-1 感染中 HIV-1 特异性 CD8 T 细胞功能谱与表位变异性与逃逸突变体选择的关系。
PLoS Pathog. 2011 Feb 10;7(2):e1001273. doi: 10.1371/journal.ppat.1001273.
7
Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C. gag 蛋白酶介导的复制能力对近期感染 HIV-1 亚型 C 的个体疾病进展的影响。
J Virol. 2011 Apr;85(8):3996-4006. doi: 10.1128/JVI.02520-10. Epub 2011 Feb 2.
8
Differences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individuals.HIV 暴露和未暴露的 HIV 血清阴性个体之间 HIV 特异性 T 细胞反应的差异。
J Virol. 2011 Apr;85(7):3507-16. doi: 10.1128/JVI.02444-10. Epub 2011 Jan 26.
9
Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection.携带 HLA Ⅱ类 DRB1*1303 与慢性 HIV-1 型 C 群和 B 群感染者病毒载量降低相关。
J Infect Dis. 2011 Mar 15;203(6):803-9. doi: 10.1093/infdis/jiq122. Epub 2011 Jan 21.
10
Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllers.CD4 T 细胞转录组分析鉴定出 HIV-1 精英控制者的不同亚群。
J Virol. 2011 Mar;85(6):3015-9. doi: 10.1128/JVI.01846-10. Epub 2010 Dec 22.
Zotero 插件