Arnoczy Gretchen S, Ferrari Guido, Goonetilleke Nilu, Corrah Tumena, Li Hui, Kuruc Joann, Schmitz John L, McGee Kara, Hicks Charles, Eron Joseph J
Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 28374, USA.
AIDS Res Hum Retroviruses. 2012 Aug;28(8):789-92. doi: 10.1089/AID.2011.0145.
Acute HIV-1 infection causes a rapid total body depletion of CD4(+) T cells in most individuals and HIV-1-specific CD8(+) T cell expansion in response to viral replication. A numerically high CD8 T cell response may indicate limited T cell repertoire against HIV and rapid progression. We present a detailed evaluation of an acutely infected individual with a strong HIV-1-specific CD8 T cell response targeting multiple epitopes demonstrating that the upper limit of CD8 expansion in this setting may be much higher than previously reported and was likely driven by the narrow HIV-specific response.
急性HIV-1感染会导致大多数个体的CD4(+) T细胞在全身迅速耗竭，并引发HIV-1特异性CD8(+) T细胞因病毒复制而扩增。数量上较高的CD8 T细胞反应可能表明针对HIV的T细胞库有限且疾病进展迅速。我们对一名急性感染个体进行了详细评估，该个体针对多个表位具有强烈的HIV-1特异性CD8 T细胞反应，结果表明在这种情况下CD8扩增的上限可能比先前报道的要高得多，并且很可能是由狭窄的HIV特异性反应驱动的。
