己酮可可碱治疗肝肺综合征。
Pentoxifylline in hepatopulmonary syndrome.
机构信息
Allergy Research Center, Ghaem Medical Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
World J Gastroenterol. 2012 Sep 21;18(35):4912-6. doi: 10.3748/wjg.v18.i35.4912.
AIM
To determine the effects of pentoxifylline (PTX) on clinical manifestations and evaluate arterial blood gas data in hepatopulmonary syndrome (HPS) in children.
METHODS
In a pilot study of 10 children with chronic liver disease, who had HPS, 20 mg/kg/d PTX was administered for 3 mo. Clinical data and arterial blood gas parameters were evaluated at baseline, the end of the treatment period, and 3 mo after drug discontinuation.
RESULTS
Six patients could tolerate PTX, while four patients experienced complications. Among patients who could tolerate PTX, there was a significant increase in arterial oxygen pressure (PaO(2)) (P = 0.02) and oxygen saturation (SaO(2)) (P = 0.04) and alveolar-arterial oxygen gradient (P = 0.02) after 3 mo of treatment. Significant decreases in PaO(2) (P = 0.02) and alveolar-arterial oxygen gradient (P = 0.02) were also seen after drug discontinuation.
CONCLUSION
PTX may improve PaO(2), SaO(2) and alveolar-arterial oxygen gradient in the early stage of HPS.
目的
评估己酮可可碱（PTX）对儿童肝肺综合征（HPS）临床表现和动脉血气数据的影响。
方法
在 10 例患有 HPS 的慢性肝病儿童的初步研究中，给予 20mg/kg/d PTX 治疗 3 个月。在基线、治疗期末和停药后 3 个月评估临床数据和动脉血气参数。
结果
6 例患者能够耐受 PTX，而 4 例患者出现并发症。在能够耐受 PTX 的患者中，治疗 3 个月后动脉血氧分压（PaO2）（P=0.02）和血氧饱和度（SaO2）（P=0.04）以及肺泡-动脉血氧分压差（P=0.02）显著升高。停药后 PaO2（P=0.02）和肺泡-动脉血氧分压差（P=0.02）也显著降低。
结论
PTX 可能在 HPS 的早期改善 PaO2、SaO2 和肺泡-动脉血氧分压差。
Zotero 插件