抗体介导的肺移植排斥反应
Antibody-Mediated Lung Transplant Rejection.
作者信息
Hachem Ramsey
机构信息
Washington University School of Medicine, Division of Pulmonary & Critical Care Medicine, 660 S. Euclid Ave., Campus Box 8052, St. Louis, MO 63110, USA,
出版信息
Curr Respir Care Rep. 2012 Sep;1(3):157-161. doi: 10.1007/s13665-012-0019-8.
Abstract
Antibody-mediated rejection after lung transplantation remains enigmatic. However, emerging evidence over the past several years suggests that humoral immunity plays an important role in allograft rejection. Indeed, the development of donor-specific antibodies after transplantation has been identified as an independent risk factor for acute cellular rejection and bronchiolitis obliterans syndrome. Furthermore, cases of acute antibody-mediated rejection resulting in severe allograft dysfunction have been reported, and these demonstrate that antibodies can directly injure the allograft. However, the incidence and toll of antibody-mediated rejection are unknown because there is no widely accepted definition and some cases may be unrecognized. Clearly, humoral immunity has become an important area for research and clinical investigation.
摘要
肺移植后抗体介导的排斥反应仍然难以捉摸。然而，过去几年出现的证据表明，体液免疫在同种异体移植排斥反应中起重要作用。事实上，移植后供体特异性抗体的产生已被确定为急性细胞排斥反应和闭塞性细支气管炎综合征的独立危险因素。此外，已有报道急性抗体介导的排斥反应导致严重的同种异体移植功能障碍的病例，这些病例表明抗体可直接损伤同种异体移植器官。然而，由于没有广泛接受的定义且一些病例可能未被识别，抗体介导的排斥反应的发生率和损害尚不清楚。显然，体液免疫已成为一个重要的研究和临床调查领域。
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