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(丁酰基)-环磷酸腺苷((Bu2)-cAMP)和克罗米芬对去性腺猴子血清中几种蛋白质和激素浓度的影响。

Effects of (Bu2)-cAMP and clomiphene on serum concentrations of several proteins and hormones in gonadectomized monkeys.

作者信息

Barbosa J, Seal U S, Doe R P

出版信息

Endocrinol Exp. 1979 Mar;13(1):19-27.

PMID:230027
Abstract

Sixteen mumol kg-1 of dibutyryl cyclic adenosine 3',5'-monophosphate [(Bu)2cAMP] given intramuscularly to gonadectomized green monkeys (Cercopithecus aetheops sabeus) for two-week periods, produced a significant elevation in the serum concentrations of thyroxine-binding globulin (TBG), fibrinogen, and haptoglobin. No changes were noted in cortisol-binding golbulin (CBG), cortisol, thyroxine, transferrin, total proteins, and albumin. Clomiphene citrate (12.5 mg orally) given concomitantly with (Bu)2cAMP blocked partially the (Bu)2cAMP-induced fibrinogen increment, but not the change in TBG concentration.

摘要

对去性腺的绿猴(食蟹猴亚种)肌肉注射16微摩尔/千克的二丁酰环磷腺苷酸[(Bu)2cAMP],为期两周,可使血清甲状腺素结合球蛋白(TBG)、纤维蛋白原和触珠蛋白的浓度显著升高。皮质醇结合球蛋白(CBG)、皮质醇、甲状腺素、转铁蛋白、总蛋白和白蛋白未见变化。与(Bu)2cAMP同时口服氯米芬柠檬酸盐(12.5毫克)可部分阻断(Bu)2cAMP诱导的纤维蛋白原增加,但不能阻断TBG浓度的变化。

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