内在抗生素耐药决定因素的失活扩大了嗜麦芽寡养单胞菌中喹诺酮类药物的突变选择窗。
The Inactivation of intrinsic antibiotic resistance determinants widens the mutant selection window for quinolones in Stenotrophomonas maltophilia.
机构信息
Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, Cantoblanco, Madrid, Spain.
出版信息
Antimicrob Agents Chemother. 2012 Dec;56(12):6397-9. doi: 10.1128/AAC.01558-12. Epub 2012 Sep 24.
Abstract
We have determined that the mutational inactivation of the SmeDEF efflux pump and the SmQnr quinolone resistance protein widens the mutant selection windows for ofloxacin and ciprofloxacin of Stenotrophomonas maltophilia by reducing their MICs. Resistant mutants arising from a strain lacking SmeDEF and SmQnr presented levels of susceptibility similar to those of the wild-type strain. This indicates that inactivation of intrinsic resistance determinants might increase the chances for selecting resistant mutants at low antibiotic concentrations.
摘要
我们已经确定，SmeDEF 外排泵和 SmQnr 喹诺酮类耐药蛋白的突变失活通过降低其 MIC 值，扩大了嗜麦芽寡养单胞菌对氧氟沙星和环丙沙星的突变选择窗口。缺乏 SmeDEF 和 SmQnr 的菌株产生的耐药突变体表现出与野生型菌株相似的敏感性水平。这表明，内在耐药决定因素的失活可能会增加在低抗生素浓度下选择耐药突变体的机会。
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