International Academy of Environmental Sciences, Venice, Italy.
Clin Chem Lab Med. 2013 Feb;51(2):413-9. doi: 10.1515/cclm-2012-0414.
In cancer patients, including women with a diagnosis of ovarian cancer, cancer antigen 125 (CA125) is used to evaluate the presence of peritoneal involvement. The aims of the present study were to assess CA125 reference intervals and reference change values (RCV) in postmenopausal reference women, postmenopausal women breast cancer free, reference men and cancer free men.
The series consisted of 433 subjects: 105 postmenopausal breast cancer free women and 56 cancer free men in addition to a total of 272 reference subjects (145 postmenopausal women and 127 men). Repeated CA125 measurements were made in a subset of 149 women and 54 men to calculate RCV and index of individuality. Serum CA125 levels were evaluated by a chemiluminescent assay.
In postmenopausal reference women, the mean CA125 value and 2.5th-97.5th percentiles were 6.70, 2.60-11.00 kU/L, respectively, with a unidirectional RCV of 38.4%. In postmenopausal breast cancer free women, the mean CA125 value and 2.5th-97.5th percentile were 7.45, 4.09-10.92 kU/L, respectively, with a RCV of 34.5%. The difference between the means was statistically significant (t=-3.02, p=0.003). In the two male subgroups, the difference between the means for CA125 was not statistically significant (t=0.43, p=0.665). On considering the entire male population, the mean CA125 value and 2.5th-97.5th percentiles were 7.50 and 2.40-13.2 kU/L, respectively, while the unidirectional RCV was 34.3%. In all the studied groups, the indices of individuality were equal to or below 0.6.
The extremely low index of individuality found underlines the importance of using the RCV instead of absolute values as a parameter when interpreting the CA125 data in the monitoring and follow-up of patients with ovarian cancer.
在癌症患者中，包括被诊断为卵巢癌的女性，癌抗原 125（CA125）用于评估腹膜受累情况。本研究的目的是评估绝经后女性、绝经后无乳腺癌女性、男性参考人群和无癌症男性的 CA125 参考区间和参考变化值（RCV）。
该系列包括 433 名受试者：105 名绝经后无乳腺癌女性和 56 名无癌症男性，以及总共 272 名参考受试者（145 名绝经后女性和 127 名男性）。对 149 名女性和 54 名男性的部分样本进行了重复 CA125 测量，以计算 RCV 和个体指数。通过化学发光测定法评估血清 CA125 水平。
在绝经后参考女性中，CA125 的平均值和 2.5 至 97.5 百分位数分别为 6.70、2.60-11.00 kU/L，RCV 为 38.4%。在绝经后无乳腺癌女性中，CA125 的平均值和 2.5 至 97.5 百分位数分别为 7.45、4.09-10.92 kU/L，RCV 为 34.5%。平均值之间的差异具有统计学意义（t=-3.02，p=0.003）。在两个男性亚组中，CA125 平均值之间的差异无统计学意义（t=0.43，p=0.665）。考虑到整个男性人群，CA125 的平均值和 2.5 至 97.5 百分位数分别为 7.50、2.40-13.2 kU/L，RCV 为 34.3%。在所有研究组中，个体指数均等于或低于 0.6。
在监测和随访卵巢癌患者时，RCV 比绝对值更适合作为解释 CA125 数据的参数，因此发现个体指数非常低，这一点非常重要。
