Simpson J W, van den Broek A H
Department of Veterinary Clinical Studies, Royal Dick School of Veterinary Studies, Summerhall, Edinburgh.
Res Vet Sci. 1990 Jan;48(1):38-41.
Fat absorption was determined quantitatively in clinically normal dogs, dogs with confirmed hyperadrenocorticalism before and after treatment with mitotane (op' DDD) and in pruritic dogs before and after administration of prednisolone. Fat absorption was significantly higher (P less than 0.001) in dogs with untreated hyperadrenocorticalism and pruritic dogs on prednisolone therapy than in normal dogs. It was normal in pruritic dogs before prednisolone therapy and approached normality in dogs with treated hyperadrenocorticalism. It is concluded that high circulating cortisol or prednisolone levels result in increased intestinal absorption of dietary fat possibly mediated by increased glucocorticoid induced activity of enterocytes or reduced hepatic clearance of triglycerides.
在临床正常的犬、确诊为肾上腺皮质功能亢进且在接受米托坦（o，p'-DDD）治疗前后的犬以及瘙痒犬在给予泼尼松龙前后，对脂肪吸收进行了定量测定。未经治疗的肾上腺皮质功能亢进犬和接受泼尼松龙治疗的瘙痒犬的脂肪吸收显著高于正常犬（P<0.001）。泼尼松龙治疗前瘙痒犬的脂肪吸收正常，肾上腺皮质功能亢进犬经治疗后脂肪吸收接近正常。结论是，高循环皮质醇或泼尼松龙水平可能通过增加糖皮质激素诱导的肠细胞活性或降低肝脏甘油三酯清除率，导致膳食脂肪的肠道吸收增加。
