Serteyn D, Mottart E, Deby C, Deby-Dupont G, Pincemail J, Philipart C, Lamy M
Service de Chirurgie, Faculté de Médecine Vétérinaire, University of Liege, Belgium.
Res Vet Sci. 1990 Jan;48(1):42-6.
A method for the evaluation of total plasma antihydroxyl and antiperferryl activity is described. This method was applied to horse plasma obtained during halothane anaesthesia. In horses suffering from postanaesthetic myositis, a significant decrease in the antiperferryl activity was observed during anaesthesia particularly when the muscular compression produced by the weight of the horse was released. In the affected muscles, strong oxidants could therefore be generated during the reperfusion of the ischaemic muscles and might initiate membrane lipid peroxidation. This phenomenon could possibly explain the muscular damage observed in equine postanaesthetic myositis.
本文描述了一种评估血浆总抗羟基和抗过氧酰基活性的方法。该方法应用于氟烷麻醉期间采集的马血浆。在患有麻醉后肌炎的马匹中，麻醉期间观察到抗过氧酰基活性显著降低，尤其是在马匹体重产生的肌肉压迫解除时。因此，在缺血肌肉再灌注期间，受影响的肌肉中可能会产生强氧化剂，并可能引发膜脂质过氧化。这种现象可能解释了马麻醉后肌炎中观察到的肌肉损伤。
