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色素性紫癜性皮病的肉芽肿变体

Granulomatous variant of pigmented purpuric dermatosis.

作者信息

Tato Berta Pérez, Marinero Escobedo Silvia, Pérez González Yosmar Carolina, Sánchez Albisua Begoña, Polimón Olabarrieta Isabel, Encabo Mayoral Beatriz, López Paloma Fernández

机构信息

Department of Dermatology, Hospital de Móstoles, Madrid, Spain.

出版信息

Am J Dermatopathol. 2012 Oct;34(7):746-8. doi: 10.1097/DAD.0b013e31823f616a.

Abstract

Granulomatous pigmented purpuric dermatosis is a rare entity. Historically, it has been seen in Asians. In this article, we report the case of a white man with this unusual variant. A 65-year-old, white man presented with a 1-year history of asymptomatic purpuric to brown papules on both lower legs and more confluent on dorsum of feet. He had an underlying history of hypertension and hyperlipidemia. Skin biopsy revealed a granulomatous lympho-histocytary inflammatory infiltrate in papillary dermis and superficial reticular dermis with extravasation of red blood cells and siderophages. Periodic acid schiff (PAS), Giemsa and Ziehl-Neelsen stains were negative. A diagnosis of granulomatous pigmented purpuric dermatosis was made. From the 10 cases reported of this granulomatous variant, 6 were associated with hyperlipidemia. We report an additional case with this association.

摘要

肉芽肿性色素性紫癜性皮病是一种罕见的疾病。从历史上看,它多见于亚洲人。在本文中,我们报告了一名患有这种不寻常变异型的白人男性病例。一名65岁的白人男性,双下肢出现无症状性紫癜至棕色丘疹已有1年病史,足部背侧更为融合。他有高血压和高脂血症病史。皮肤活检显示乳头真皮和浅表网状真皮有肉芽肿性淋巴细胞-组织细胞炎性浸润,伴有红细胞和含铁血黄素细胞外渗。过碘酸希夫(PAS)、吉姆萨和齐尔-尼尔森染色均为阴性。诊断为肉芽肿性色素性紫癜性皮病。在已报道的10例这种肉芽肿变异型病例中,6例与高脂血症有关。我们报告了另外1例有这种关联的病例。

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