与色素性紫癜性皮病相关的肉芽肿性改变。
Granulomatous changes associated with pigmented purpuric dermatosis.
作者信息
Morrissey Kelly, Rosenbach Misha, DeHoratius Danielle, Elenitsas Rosalie, Tetzlaff Michael T
机构信息
Department of Pathology, Section of Dermatopathology, University of Texas MD Anderson Cancer Center, 1515 Holcomb Blvd, Unit 85, Houston, TX 77030, USA.
出版信息
Cutis. 2014 Oct;94(4):197-202.
Granulomatous pigmented purpuric dermatosis (GPPD) is a rare entity with few cases reported in the literature. We report 3 cases of pigmented purpuric dermatosis (PPD) with granulomatous features in a 9-year-old boy, a 49-year-old woman, and a 75-year-old woman. We also review the literature on PPDs with granulomatous features, including histopathologic features and disease associations. Most of the cases we reviewed described granulomas superimposed on classic changes of PPD. We also identify a new variant of GPPD in 2 of our patients who presented with granulomatous infiltrates in the mid to deep dermis. Granulomatous PPD does not appear to have a consistent association with underlying disease; notably, hyperlipidemia was seen in 7 cases we reviewed.
肉芽肿性色素性紫癜性皮病（GPPD）是一种罕见的疾病，文献报道的病例较少。我们报告了3例色素性紫癜性皮病（PPD），分别为一名9岁男孩、一名49岁女性和一名75岁女性，均具有肉芽肿性特征。我们还回顾了有关具有肉芽肿性特征的PPD的文献，包括组织病理学特征和疾病关联。我们回顾的大多数病例描述了肉芽肿叠加在PPD的典型变化之上。我们还在2例患者中发现了一种新的GPPD变体，其真皮中层至深层出现肉芽肿浸润。肉芽肿性PPD似乎与潜在疾病没有一致的关联；值得注意的是，在我们回顾的7例病例中发现了高脂血症。
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