Department of Radiology, University of Pittsburgh, PET Facility-B-932, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
Nat Rev Rheumatol. 2012 Dec;8(12):719-28. doi: 10.1038/nrrheum.2012.148. Epub 2012 Sep 25.
Molecular and multimodal imaging procedures that complement the use of existing anatomical modalities for the diagnosis and monitoring of rheumatoid arthritis (RA) have undergone substantial developmental advances. These techniques have the potential to greatly improve the management of patients with RA through early diagnosis and maximization of the newly available opportunities for early therapeutic intervention. Quantitative, noninvasive monitoring of biomarkers of the molecular events induced during the onset of RA could be used to guide the initial selection of therapy and for assessment of early therapeutic responses. Biomolecular imaging techniques that can reveal the pathophysiological features of RA--including infrared thermography, near-infrared molecular imaging, and PET--are being used to investigate the earliest cellular and biochemical inflammatory events in the development of the disease. Noninvasive imaging of abnormal specific molecular events in early RA could enable early targeted intervention that could be tailored to optimize patient responses before destructive anatomical changes occur. In this Review, we summarize new advances in biomolecular imaging techniques, with an emphasis on their current state of development in terms of the management of RA.
补充现有解剖学方法用于类风湿关节炎（RA）诊断和监测的分子和多模态成像程序已经取得了实质性的发展进步。这些技术有可能通过早期诊断和充分利用新的早期治疗干预机会，极大地改善 RA 患者的治疗管理。对 RA 发病过程中诱导的分子事件的生物标志物进行定量、非侵入性监测，可用于指导初始治疗选择和评估早期治疗反应。生物分子成像技术可以揭示 RA 的病理生理特征，包括红外热成像、近红外分子成像和 PET，这些技术正被用于研究疾病发展过程中最早的细胞和生化炎症事件。在早期 RA 中对异常特定分子事件进行非侵入性成像，可以实现早期靶向干预，从而在破坏性解剖结构改变发生之前，根据患者的反应进行优化调整。在这篇综述中，我们总结了生物分子成像技术的新进展，重点介绍了它们在 RA 管理方面的当前发展状况。
