Riesgo Rudimar, Winckler Maria Isabel, Ohlweiler Lygia, Ranzan Josiane, Becker Michele, Salvador Socrates, Magalhaes Luiza, Ribeiro Ricardo
Child Neurology Unit, Department of Pediatrics, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil.
Neuropediatrics. 2012 Dec;43(6):353-6. doi: 10.1055/s-0032-1327771. Epub 2012 Sep 24.
The objective of this study is to describe the usefulness of topiramate in refractory neonatal seizures.
We reported the clinical off-label use of topiramate in three cases of refractory neonatal seizures of unclear origin with no response to conventional antiepileptic drugs. In all cases, the seizures were completely controlled with adding topiramate. All patients became seizure free during hospitalization and were followed by approximately 1 year after hospital discharge, with monotherapy with topiramate.
The clinical off-label use of topiramate in neonatal seizures is still incipient. When searching publications in this matter, only one report was identified. Because of its efficacy for both seizures and neuroprotection, topiramate could be a useful choice in refractory neonatal seizures.
本研究的目的是描述托吡酯在难治性新生儿惊厥中的作用。
我们报告了托吡酯在3例病因不明的难治性新生儿惊厥中的临床超说明书用药情况，这些惊厥对传统抗癫痫药物无反应。在所有病例中，加用托吡酯后惊厥完全得到控制。所有患者在住院期间惊厥停止，出院后接受托吡酯单药治疗，随访约1年。
托吡酯在新生儿惊厥中的临床超说明书用药仍处于初期阶段。在搜索关于此事的出版物时，仅找到一份报告。由于托吡酯对惊厥和神经保护均有效，它可能是难治性新生儿惊厥的一个有用选择。
