Department of Biological Sciences, Seoul National University, Seoul, 151-747, Korea.
Cell Mol Life Sci. 2013 Aug;70(15):2623-36. doi: 10.1007/s00018-012-1165-4. Epub 2012 Sep 25.
The vast majority of mammalian testes are located outside the body cavity for proper thermoregulation. Heat has an adverse effect on mammalian spermatogenesis and eventually leads to sub- or infertility. Recent studies have provided insights into the molecular response of male germ cells to high temperatures. Here, we review the effects of heat on male germ cells and discuss the mechanisms underlying germ cell loss and impairment. We also discuss the role of translational control in male germ cells as a potential protective mechanism against heat-induced germ cell apoptosis.
绝大多数哺乳动物的睾丸位于体腔外,以进行适当的体温调节。高温对哺乳动物的精子发生有不利影响,最终导致生殖能力下降或不育。最近的研究提供了对雄性生殖细胞对高温的分子反应的深入了解。在这里,我们回顾了高温对雄性生殖细胞的影响,并讨论了导致生殖细胞损失和功能障碍的机制。我们还讨论了翻译控制在雄性生殖细胞中的作用,作为一种潜在的针对热诱导生殖细胞凋亡的保护机制。