Department of Head and Neck Surgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA.
Laryngoscope. 2013 Feb;123(2):334-8. doi: 10.1002/lary.23477. Epub 2012 Sep 24.
Actinomycosis is a rare anaerobic bacterial infection typically caused by Actinomyces israelii. Although part of normal flora in the oral cavity, and respiratory and digestive tracts, A israelii can give rise to pathologic infections most commonly reported in the oral cavity from odontogenic causes. We present a rare case of invasive actinomycosis presenting with extensive midface destruction involving the maxilla and paranasal sinuses, with mucosal necrosis mimicking an aggressive neoplasm. The diagnosis is usually reached only after histopathologic analysis showing characteristic sulfur granules with filamentous gram-positive, non-acid-fast bacteria. We review the literature on its epidemiology, clinical presentation, diagnosis, treatment, and prognosis.
放线菌病是一种罕见的厌氧细菌感染，通常由衣氏放线菌引起。虽然它是口腔、呼吸道和消化道正常菌群的一部分，但 A. israelii 可引起病理感染，最常报道的感染部位是口腔，源于牙源性原因。我们报告了一例罕见的侵袭性放线菌病病例，表现为广泛的面中部破坏，累及上颌骨和鼻旁窦，伴有粘膜坏死，类似于侵袭性肿瘤。只有通过组织病理学分析显示出具有特征性硫磺颗粒的丝状革兰阳性、非抗酸细菌，才能做出明确诊断。我们回顾了其流行病学、临床表现、诊断、治疗和预后的文献。
