Telmesani Abdulwahab M A, Ghazi Hani O
Faculty of Medicine and Medical Science, Umm Al-Qura University, Makkah, Saudi Arabia.
J Family Community Med. 2002 May;9(2):23-6.
This study was carried out to assess the prevalence of Group A Streptococcal (GAS) bacteria in the throat specimens of children with tonsillitis and pharyngitis compared to healthy children of the same age group.
The study was a prospective one. Throat swabs were obtained from 73 children aged 1-12 years diagnosed with acute tonsillitis and pharyngitis (sore throat and pyrexia >38.5°C) visiting a pediatric outpatient clinic between December, 1999 and April, 2000. In the same period throat swabs were obtained from 465 healthy primary school children aged 6-12 years. GAS from patients was tested for sentivity to penicillin, erythromycin, and cefaclor.
In children with tonsillitis and pharyngitis GAS was found in 29 out of 73 (40%). In healthy school children GAS was found in 15 out of 465 (3%).In the patients group GAS was sensitive to penicillin in 14(48%), erythromycin in 27(93%), and cefaclor in 28(96%)
Although the prevalence of GAS among healthy children was similar to international studies, the GAS infection was high among children with acute tonsillitis and pharyngitis. Sensitivity to penicillin was less than 50% and more than 90% for erythromycin and cefaclor. We recommend routine throat swab for children with acute tonsillitis and pharyngitis and the proper treatment of GAS positive patients to prevent further complications.
本研究旨在评估与同年龄组健康儿童相比，患有扁桃体炎和咽炎的儿童咽喉标本中A组链球菌（GAS）细菌的患病率。
该研究为前瞻性研究。1999年12月至2000年4月期间，从一家儿科门诊就诊的73名1至12岁被诊断为急性扁桃体炎和咽炎（喉咙痛且发热>38.5°C）的儿童中获取咽喉拭子。同期，从465名6至12岁的健康小学生中获取咽喉拭子。对患者的GAS进行青霉素、红霉素和头孢克洛的敏感性测试。
在患有扁桃体炎和咽炎的儿童中，73例中有29例（40%）检测出GAS。在健康学童中，465例中有15例（3%）检测出GAS。在患者组中，GAS对青霉素敏感的有14例（48%），对红霉素敏感的有27例（93%），对头孢克洛敏感的有28例（96%）。
尽管健康儿童中GAS的患病率与国际研究相似，但急性扁桃体炎和咽炎儿童中的GAS感染率较高。对青霉素的敏感性低于50%，而对红霉素和头孢克洛的敏感性超过90%。我们建议对患有急性扁桃体炎和咽炎的儿童进行常规咽喉拭子检测，并对GAS阳性患者进行适当治疗以预防进一步并发症。
