Zawar Vijay
Shreeram Sankul, Opp Hotel Panchavati, Vakilwadi, Nashik-422001, Maharashtra, India.
Skinmed. 2012 Jul-Aug;10(4):257-8.
A 32-year-old man was referred for acute onset of pruritic scaly eruptions in the axillae of 8 days' duration, which was unresponsive to topical clotrimazole. The lesions consisted of multiple, coalescent oval plaques of 1 cm to 6 cm in longest diameter (Figure 1 and Figure 2) with central clearing and typical collarette scales at the periphery (Figure 3). Other skin areas and mucosal surfaces were unaffected. His general and systemic examinations were normal. Family and past histories were unremarkable except for a "ring worm-like patch" on his lower aspect of the abdomen 4 months ago, which rapidly regressed. On further inquiry, he gave a history of an episode of fever, coryza, and headache 3 weeks earlier to his eruption on the abdomen, which resolved with conservative remedies and one paracetamol tablet. He remained asymptomatic until axillary lesions appeared. We made a provisional diagnosis of pityriasis rosea (PR). Investigations including scrapings for potassium hydroxide examination, complete blood cell counts, urinalysis, blood sugar, VDRL test, and human immunodeficiency virus antibodies were all normal or non-reactive. As cutaneous biopsy revealed parakeratosis, epidermal spongiosis, dermal inflammatory cells, and extravasated red blood cells (Figure 4). The eruptions cleared within 8 days, following treatment with mometasone furoate cream and oral desloratidine 5 mg/d, leaving post-inflammatory hyperpigmentation. There was no recurrence for the next 6 months of observation. He was later lost to follow-up.
一名32岁男性因腋窝出现瘙痒性鳞屑疹8天前来就诊,外用克霉唑无效。皮疹表现为多个融合的椭圆形斑块,最长直径为1厘米至6厘米(图1和图2),中央有消退区,周边有典型的领圈状鳞屑(图3)。其他皮肤部位和黏膜表面未受累。他的全身检查正常。家族史和既往史无特殊,仅4个月前腹部下方有一个“癣样斑块”,但迅速消退。进一步询问得知,他在腹部皮疹出现前3周有发热、鼻炎和头痛史,经保守治疗和服用一片对乙酰氨基酚后症状缓解。在腋窝皮疹出现之前他一直无症状。我们初步诊断为玫瑰糠疹(PR)。包括氢氧化钾涂片检查、全血细胞计数、尿液分析、血糖、性病研究实验室试验(VDRL)和人类免疫缺陷病毒抗体检测在内的各项检查均正常或呈阴性。皮肤活检显示有角化不全、表皮海绵形成、真皮炎症细胞和红细胞外渗(图4)。外用糠酸莫米松乳膏和口服地氯雷他定5毫克/天治疗8天后皮疹消退,遗留炎症后色素沉着。在接下来6个月的观察期内未复发。他后来失访了。