Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Room H7.22, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada.
J Clin Lipidol. 2012 Sep-Oct;6(5):427-33. doi: 10.1016/j.jacl.2012.04.081. Epub 2012 May 1.
To characterize the composition of very-low-density lipoprotein (VLDL) particles and the proportion of VLDL to total apolipoprotein B (apoB) particles in patients with hypertriglyceridemia caused by excess VLDL.
Subjects were selected from 2023 consecutive patients attending the Lipid Clinic at the Laval University Centre. Plasma lipids, apoB, and apoA-I were measured and chylomicron lipids and VLDL and LDL lipids and apoB determined after ultracentrifugation. Patients with hypertriglyceridemia caused by excess VLDL were divided into four groups on the basis of triglyceride and apoB.
A total of 440 controls, 387 subjects with normotriglyceridemic hyperapoB, 38 with type III dysbetalipoproteinemia, 270 with mild hypertriglyceridemic normoapoB, 163 with moderate hypertriglyceridemic normoapoB, 458 with mild hypertriglyceridemic hyperapoB, and 295 subjects with moderate hypertriglyceridemic hyperapoB were compared. In patients with hypertriglyceridemia caused by excess VLDL, the VLDL particles were triglyceride and cholesterol-enriched. HyperapoB is associated with greater low-density lipoprotein (LDL) apoB than normoapoB, whereas greater triglycerides are associated with greater VLDL apoB. Thus, the ratio of VLDL apoB/total apoB was significantly less in those with mild hypertriglyceridemia compared with those with moderate hypertriglyceridemia, irrespective of the plasma apoB.
The apoB phenotypes in hypertriglyceridemia caused by excess VLDL appear to be determined by the extent to which VLDL secretion increases, the extent to which VLDL particles can be converted to LDL particles, and the effects of core lipid exchange. More accurate characterization of hypertriglyceridemia caused by excess VLDL should lead to a better understanding of the determinants of VLDL clearance and conversion to LDL as well as of the atherogenic potential of VLDL.
描述由富含甘油三酯的极低密度脂蛋白(VLDL)引起的高甘油三酯血症患者的 VLDL 颗粒组成和 VLDL 与总载脂蛋白 B (apoB)颗粒的比例。
从在拉瓦尔大学中心脂质诊所就诊的 2023 例连续患者中选择研究对象。测量血浆脂质、apoB 和 apoA-I，并在超速离心后确定乳糜微粒脂质、VLDL 和 LDL 脂质以及 apoB。根据甘油三酯和 apoB 将由富含 VLDL 的 VLDL 引起的高甘油三酯血症患者分为四组。
共比较了 440 例对照、387 例非高甘油三酯血症高 apoB 患者、38 例 III 型脂血症、270 例轻度高甘油三酯血症正常 apoB 患者、163 例中度高甘油三酯血症正常 apoB 患者、458 例轻度高甘油三酯血症高 apoB 患者和 295 例中度高甘油三酯血症高 apoB 患者。在由富含 VLDL 的 VLDL 引起的高甘油三酯血症患者中，VLDL 颗粒富含甘油三酯和胆固醇。高 apoB 与 LDL apoB 比正常 apoB 更大，而更大的甘油三酯与更大的 VLDL apoB 相关。因此，无论血浆 apoB 如何，轻度高甘油三酯血症患者的 VLDL apoB/总 apoB 比值明显低于中度高甘油三酯血症患者。
由富含 VLDL 的 VLDL 引起的高甘油三酯血症的 apoB 表型似乎由 VLDL 分泌增加的程度、VLDL 颗粒转化为 LDL 颗粒的程度以及核心脂质交换的影响决定。对由富含 VLDL 的 VLDL 引起的高甘油三酯血症进行更准确的描述，应能更好地了解 VLDL 清除和转化为 LDL 的决定因素以及 VLDL 的致动脉粥样硬化潜力。
