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血浆置换治疗原位心脏移植术后严重高甘油三酯血症性胰腺炎。

Plasma exchange for severe hypertriglyceridemia-induced pancreatitis in an orthotopic heart transplant recipient.

机构信息

Emory University School of Medicine, 1365 Clifton Road, NE Building A, Suite 2200, Atlanta, GA 30322, USA.

出版信息

J Clin Lipidol. 2012 Sep-Oct;6(5):474-6. doi: 10.1016/j.jacl.2012.01.003. Epub 2012 Jan 21.

DOI:10.1016/j.jacl.2012.01.003
PMID:23009784
Abstract

We here report a 33-year old male with diabetes, hypertension and history of orthotopic heart transplantation treated by plasma exchange for severe HTG (hypertriglyceridemia) induced pancreatitis. At the time of presentation, his serum TG (triglyceride) level was 10,278 mg/dL. He underwent one of the three planned sessions of plasma exchange, resulting in a decrease in TG level from 4728 mg/dL to 1708 mg/dL. The hospital course was complicated with shock, hemorrhagic transformation of the pancreatitis and acute respiratory distress syndrome. This prevented any further plasma exchange sessions. He was subsequently discharged home in a stable state and TG level of 80 mg/dL. Plasma exchange can be safely used to manage HTG induced pancreatitis in heart transplant recipients.

摘要

我们在此报告一例 33 岁男性,患有糖尿病、高血压和原位心脏移植史,因严重高甘油三酯血症(HTG)引起的胰腺炎接受血浆置换治疗。就诊时,他的血清甘油三酯(TG)水平为 10278mg/dL。他接受了计划中的三次血浆置换中的一次,TG 水平从 4728mg/dL 降至 1708mg/dL。住院期间出现休克、胰腺炎出血性转化和急性呼吸窘迫综合征,这使得无法进行进一步的血浆置换。随后,他在稳定状态下出院,TG 水平为 80mg/dL。血浆置换可安全用于管理心脏移植受者的 HTG 诱导的胰腺炎。

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Plasmapheresis for Hypertriglyceridemia-induced Acute Pancreatitis: A Systematic Review and Meta-summary of Case Reports.血浆置换治疗高甘油三酯血症性急性胰腺炎:病例报告的系统评价和Meta总结
Indian J Crit Care Med. 2025 Jul;29(7):604-611. doi: 10.5005/jp-journals-10071-25010. Epub 2025 Jul 7.
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Post-transplant dyslipidemia: Mechanisms, diagnosis and management.移植后血脂异常:机制、诊断与管理
World J Transplant. 2016 Mar 24;6(1):125-34. doi: 10.5500/wjt.v6.i1.125.
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Successful Plasma Exchange for Acute Pancreatitis Complicated With Hypertriglyceridemia: A Case Report.
成功应用血浆置换治疗急性胰腺炎合并高甘油三酯血症:一例报告
J Investig Med High Impact Case Rep. 2015 Sep 10;3(3):2324709615605635. doi: 10.1177/2324709615605635. eCollection 2015 Jul-Sep.