Bogsrud T V, Rootwelt K, Russell D, Nyberg-Hansen R
Department of Clinical Chemistry, Rikshospitalet, Oslo, Norway.
Stroke. 1990 Jan;21(1):52-5. doi: 10.1161/01.str.21.1.52.
We studied the effect of acetazolamide on cerebellar blood flow in 11 stroke patients with large, unilateral cerebral hemispheric infarcts and no evidence of cerebellar infarction, but with cerebrocerebellar diaschisis of cerebral blood flow. Blood flow was determined with xenon-133 inhalation and dynamic single-photon emission computed tomography at rest and 20 minutes after the intravenous injection of 1.0 g acetazolamide. After acetazolamide, the mean +/- SD increases in blood flow in the affected and contralateral cerebellar hemispheres were 11.1 +/- 3.7 and 12.0 +/- 5.3 ml/100 g/min, respectively; the difference between hemispheres was not significant. The absolute increase in cerebellar flow in these 11 patients was of the same magnitude as that in 12 healthy controls. We conclude that cerebellar vasoreactivity is intact in stroke patients with crossed cerebrocerebellar diaschisis of cerebral blood flow. Our results lend further support to the concept that reduced cerebellar blood flow is secondary to functional deactivation. Our patients were studied 2 weeks to 5 years after their stroke, indicating that this phenomenon may be persistent.
我们研究了乙酰唑胺对11例患有大面积单侧大脑半球梗死且无小脑梗死证据，但存在脑血流性脑-小脑失联络的中风患者小脑血流的影响。通过吸入氙-133以及在静息状态和静脉注射1.0 g乙酰唑胺后20分钟进行动态单光子发射计算机断层扫描来测定血流。注射乙酰唑胺后，患侧和对侧小脑半球血流的平均增加量（±标准差）分别为11.1±3.7和12.0±5.3 ml/100 g/min；半球间差异不显著。这11例患者小脑血流的绝对增加量与12例健康对照者的增加量幅度相同。我们得出结论，在存在交叉性脑-小脑血流性失联络的中风患者中，小脑血管反应性是完整的。我们的结果进一步支持了小脑血流减少是继发于功能失活这一概念。我们的患者在中风后2周至5年接受研究，表明这种现象可能持续存在。
