Department of Materials Science and Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China.
Colloids Surf B Biointerfaces. 2013 Jan 1;101:228-35. doi: 10.1016/j.colsurfb.2012.06.026. Epub 2012 Jul 11.
Naproxen (Nap) is a commonly used drug for antiphlogosis and analgesia, but its dissolution rate in water is quite low. In this work, the dissolution behavior of Nap after loading in mesoporous silica materials was investigated in a simulated intestinal fluid (pH=6.8). The results indicated that the pore sizes, morphologies and surface chemical groups of the mesoporous silica were significant factors on the dissolution behavior of Nap. The physical state of encapsulated Nap was affected by the pore sizes of mesoporous silica, which influenced its dissolution rate. Amorphous Nap exhibited a higher dissolution rate than crystallized Nap, even though the larger pore size could facilitate its diffusion from the matrix. The effect of the morphology of mesoporous silicas on the dissolution of Nap can be ascribed to the length of pore channels, that the longer channel showed a longer diffusion pathway of Nap. Moreover, the release rate of Nap from functionalized mesoporous materials was effectively controlled compared with that of unmodified materials.
萘普生（Nap）是一种常用的抗炎和镇痛药物，但它在水中的溶解速率相当低。在这项工作中，研究了介孔硅材料负载萘普生后在模拟肠液（pH=6.8）中的溶解行为。结果表明，介孔硅的孔径、形态和表面化学基团是影响萘普生溶解行为的重要因素。介孔硅的孔径影响了包裹萘普生的物理状态，从而影响了其溶解速率。无定形萘普生的溶解速率高于结晶萘普生，尽管较大的孔径有利于其从基质中扩散。介孔硅形态对萘普生溶解的影响可以归因于孔道的长度，较长的通道显示出萘普生较长的扩散途径。此外，与未改性材料相比，功能化介孔材料能够有效地控制萘普生的释放速率。
