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肝细胞膜中催乳素受体的中枢控制:下丘脑去传入神经的影响。

Central control of lactogenic receptors in liver membranes: effect of hypothalamic deafferentation.

作者信息

Norstedt G, Eneroth P, Gustafsson J A, Hökfelt T, Skett P

出版信息

Mol Cell Endocrinol. 1979 Dec;16(3):199-204. doi: 10.1016/0303-7207(79)90026-1.

DOI:10.1016/0303-7207(79)90026-1
PMID:230104
Abstract

The regulation by the central nervous system of a lactogenic receptor, present in the rat liver, was studied. The receptor, which is present in very low concentration or absent in the male rat, can be induced by anterior hypothalamic deafferentation, resulting in a typically female level of the receptor in lesioned male animals. Our observations indicate an important role of the brain in regulation of peripheral lactogenic receptors.

摘要

对大鼠肝脏中存在的催乳素受体受中枢神经系统调控的情况进行了研究。该受体在雄性大鼠中浓度极低或不存在,可通过下丘脑前部去传入诱导产生,导致损伤的雄性动物体内该受体达到典型的雌性水平。我们的观察结果表明大脑在调节外周催乳素受体方面具有重要作用。

相似文献

1
Central control of lactogenic receptors in liver membranes: effect of hypothalamic deafferentation.肝细胞膜中催乳素受体的中枢控制:下丘脑去传入神经的影响。
Mol Cell Endocrinol. 1979 Dec;16(3):199-204. doi: 10.1016/0303-7207(79)90026-1.
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Role of the hypothalamo-pituitary-liver axis in sex differences in susceptibility of the liver to toxic agents.下丘脑-垂体-肝脏轴在肝脏对毒性物质易感性的性别差异中的作用。
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Central control of hepatic steroid metabolism and "lactogenic" receptor.
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Induction of a lactogenic receptor in rat liver: influence of estrogen and the pituitary.大鼠肝脏中催乳素受体的诱导:雌激素和垂体的影响。
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Stimulatory and inhibitory effects of ovarian steroids on gonadotrophin secretion in ovariectomized rats after anterior hypothalamic deafferentation.下丘脑前部去传入神经后卵巢类固醇对去卵巢大鼠促性腺激素分泌的刺激和抑制作用。
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Effects of hypophysectomy, ovariectomy, and cycloheximide on specific binding sites for lactogenic hormones in rat liver.垂体切除、卵巢切除及环己酰亚胺对大鼠肝脏中催乳激素特异性结合位点的影响。
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引用本文的文献

1
Role of the hypothalamo-pituitary-liver axis in sex differences in susceptibility of the liver to toxic agents.下丘脑-垂体-肝脏轴在肝脏对毒性物质易感性的性别差异中的作用。
Environ Health Perspect. 1981 Apr;38:129-41. doi: 10.1289/ehp.8138129.